The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2023
In Utero Exposure to Maternal Electronic Nicotine Delivery System use Demonstrate Alterations to Craniofacial Development.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Kishinchand Rajiv, Boyce Mark, Vyas Heema, Sewell Leslie, Mohi Amr, Brengartner Lexie, Miller Roy, Gorr Matthew W, Wold Loren E, Cray James
Аннотация
OBJECTIVE: Develop a model for the study of Electronic Nicotine Device (ENDS) exposure on craniofacial development.
DESIGN: Experimental preclinical design followed as pregnant murine dams were randomized and exposed to filtered air exposure, carrier exposure consisting of 50% volume of propylene glycol and vegetable glycine (ENDS Carrier) respectively, or carrier exposure with 20 mg/ml of nicotine added to the liquid vaporizer (ENDS carrier with nicotine).
SETTING: Preclinical murine model exposure using the SciReq exposure system.
PARTICIPANTS: C57BL6 adult 8 week old female pregnant mice and exposed in utero litters.
INTERVENTIONS: Exposure to control filtered air, ENDS carrier or ENDS carrier with nicotine added throughout gestation at 1 puff/minute, 4 h/day, five days a week.
MAIN OUTCOME MEASURES: Cephalometric measures of post-natal day 15 pups born as exposed litters.
RESULTS: Data suggests alterations to several facial morphology parameters in the developing offspring, suggesting electronic nicotine device systems may alter facial growth if used during pregnancy.
CONCLUSIONS: Future research should concentrate on varied formulations and exposure regimens of ENDS to determine timing windows of exposures and ENDS formulations that may be harmful to craniofacial development.
DESIGN: Experimental preclinical design followed as pregnant murine dams were randomized and exposed to filtered air exposure, carrier exposure consisting of 50% volume of propylene glycol and vegetable glycine (ENDS Carrier) respectively, or carrier exposure with 20 mg/ml of nicotine added to the liquid vaporizer (ENDS carrier with nicotine).
SETTING: Preclinical murine model exposure using the SciReq exposure system.
PARTICIPANTS: C57BL6 adult 8 week old female pregnant mice and exposed in utero litters.
INTERVENTIONS: Exposure to control filtered air, ENDS carrier or ENDS carrier with nicotine added throughout gestation at 1 puff/minute, 4 h/day, five days a week.
MAIN OUTCOME MEASURES: Cephalometric measures of post-natal day 15 pups born as exposed litters.
RESULTS: Data suggests alterations to several facial morphology parameters in the developing offspring, suggesting electronic nicotine device systems may alter facial growth if used during pregnancy.
CONCLUSIONS: Future research should concentrate on varied formulations and exposure regimens of ENDS to determine timing windows of exposures and ENDS formulations that may be harmful to craniofacial development.