Archives of general psychiatry · 2011
Development of lifetime comorbidity in the World Health Organization world mental health surveys.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
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Kessler Ronald C, Ormel Johan, Petukhova Maria, McLaughlin Katie A, Green Jennifer Greif, Russo Leo J, Stein Dan J, Zaslavsky Alan M, Aguilar-Gaxiola Sergio, Alonso Jordi, Andrade Laura, Benjet Corina, de Girolamo Giovanni, de Graaf Ron, Demyttenaere Koen, Fayyad John, Haro Josep Maria, Hu Chi yi, Karam Aimee, Lee Sing, Lepine Jean-Pierre, Matchsinger Herbert, Mihaescu-Pintia Constanta, Posada-Villa Jose, Sagar Rajesh, Ustün T Bedirhan
Аннотация
BACKGROUND: Familial aggregation of dementia with Lewy bodies (DLB) remains unclear.
OBJECTIVES: To determine the degree of family aggregation of DLB by comparing DLB risk between siblings of probands with clinically diagnosed DLB and siblings of probands with clinically diagnosed Alzheimer disease in a cohort of Caribbean Hispanic families and to explore the degree of aggregation of specific clinical manifestations (ie, cognitive fluctuations, visual hallucinations, and parkinsonism) in DLB.
DESIGN: Familial cohort study.
SETTING: Academic research.
PATIENTS: We separately compared risks of possible DLB, probable DLB, and clinical core features of DLB (cognitive fluctuations, visual hallucinations, and parkinsonism) between siblings of probands with clinically diagnosed DLB (n = 344) and siblings of probands with clinically diagnosed Alzheimer disease (n = 280) in 214 Caribbean Hispanic families with extended neurologic and neuropsychological assessment.
MAIN OUTCOME MEASURES: We applied general estimating equations to adjust for clustering within families. In these models, age and proband disease status were independent variables, and disease status of siblings was the measure of disease risk and the dependent variable.
RESULTS: Compared with siblings of probands having clinically diagnosed Alzheimer disease, siblings of probands having clinically diagnosed DLB had higher risks of probable DLB (odds ratio [OR], 2.29; 95% confidence interval [CI], 1.04-5.04) and visual hallucinations (2.32; 1.16-4.64). They also had increased risks of possible DLB (OR, 1.51; 95% CI, 0.97-2.34) and cognitive fluctuations (1.55; 0.95-2.53).
CONCLUSIONS: Dementia with Lewy bodies and core features of DLB aggregate in families. Compared with siblings of probands having clinically diagnosed AD, siblings of probands having clinically diagnosed DLB are at increased risks of DLB and visual hallucinations. These findings are an important step in elucidating the genetic risk factors underlying DLB and in delineating DLB from other neurodegenerative diseases, such as Alzheimer disease.
OBJECTIVES: To determine the degree of family aggregation of DLB by comparing DLB risk between siblings of probands with clinically diagnosed DLB and siblings of probands with clinically diagnosed Alzheimer disease in a cohort of Caribbean Hispanic families and to explore the degree of aggregation of specific clinical manifestations (ie, cognitive fluctuations, visual hallucinations, and parkinsonism) in DLB.
DESIGN: Familial cohort study.
SETTING: Academic research.
PATIENTS: We separately compared risks of possible DLB, probable DLB, and clinical core features of DLB (cognitive fluctuations, visual hallucinations, and parkinsonism) between siblings of probands with clinically diagnosed DLB (n = 344) and siblings of probands with clinically diagnosed Alzheimer disease (n = 280) in 214 Caribbean Hispanic families with extended neurologic and neuropsychological assessment.
MAIN OUTCOME MEASURES: We applied general estimating equations to adjust for clustering within families. In these models, age and proband disease status were independent variables, and disease status of siblings was the measure of disease risk and the dependent variable.
RESULTS: Compared with siblings of probands having clinically diagnosed Alzheimer disease, siblings of probands having clinically diagnosed DLB had higher risks of probable DLB (odds ratio [OR], 2.29; 95% confidence interval [CI], 1.04-5.04) and visual hallucinations (2.32; 1.16-4.64). They also had increased risks of possible DLB (OR, 1.51; 95% CI, 0.97-2.34) and cognitive fluctuations (1.55; 0.95-2.53).
CONCLUSIONS: Dementia with Lewy bodies and core features of DLB aggregate in families. Compared with siblings of probands having clinically diagnosed AD, siblings of probands having clinically diagnosed DLB are at increased risks of DLB and visual hallucinations. These findings are an important step in elucidating the genetic risk factors underlying DLB and in delineating DLB from other neurodegenerative diseases, such as Alzheimer disease.
Предметные рубрики MeSH
AdultAgedAnxietyAttention Deficit and Disruptive Behavior DisordersComorbidityFemaleHealth SurveysHumansInternational CooperationMaleMental DisordersMental HealthMiddle AgedModels, PsychologicalMood DisordersObsessive-Compulsive DisorderPhobic DisordersPsychomotor AgitationRisk FactorsSubstance-Related DisordersTime FactorsWorld Health Organization