Cardiovascular and interventional radiology · 2025
Safety and Efficacy of Absorbable Biliary Stents for Benign Bile Duct Strictures: A Systematic Review and Meta-Analysis.
Систематический обзорСтатьяМетаанализНазвание и аннотация: Перевод в очереди
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Dreifuss Nicolás H, McCormack Lucas, Capitanich Pablo, Mendez Patricio, Eyheremendy Eduardo, Angeramo Cristian A
Аннотация
PURPOSE: This study aims to assess the safety and clinical outcomes of novel biodegradable biliary stents (BDBS) in the treatment of benign biliary strictures (BBS).
MATERIALS AND METHODS: A systematic literature search on BDBS placement for BBS was conducted in Medline. Studies reporting technical success, clinical success, and BBS recurrence rates were included. A meta-analysis of proportions was used to determine each of the outcomes.
RESULTS: Twelve studies involving 384 patients who underwent 387 BDBS placement for BBS were included. The weighted pooled proportion of technical success was 100% (95% CI 92-100%). After a mean follow-up of 23.3 months, the weight average clinical success was 81% (95% CI 76-85%) and stricture recurrence was 20% (95% CI 14-27%). The mean time to relapse was 11.8 months. Stent migration, complication, and readmission rate were 3% (95% CI 2-6%), 11% (95% CI 5-22%), and 2% (95% CI 0-100%), respectively. No mortality was reported.
CONCLUSION: BDBS placement is safe and effective treatment for BBS, with high technical and clinical success with acceptable complication and migration rates.
LEVEL OF EVIDENCE: Level 3.
MATERIALS AND METHODS: A systematic literature search on BDBS placement for BBS was conducted in Medline. Studies reporting technical success, clinical success, and BBS recurrence rates were included. A meta-analysis of proportions was used to determine each of the outcomes.
RESULTS: Twelve studies involving 384 patients who underwent 387 BDBS placement for BBS were included. The weighted pooled proportion of technical success was 100% (95% CI 92-100%). After a mean follow-up of 23.3 months, the weight average clinical success was 81% (95% CI 76-85%) and stricture recurrence was 20% (95% CI 14-27%). The mean time to relapse was 11.8 months. Stent migration, complication, and readmission rate were 3% (95% CI 2-6%), 11% (95% CI 5-22%), and 2% (95% CI 0-100%), respectively. No mortality was reported.
CONCLUSION: BDBS placement is safe and effective treatment for BBS, with high technical and clinical success with acceptable complication and migration rates.
LEVEL OF EVIDENCE: Level 3.