Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke · 2008
[Genetic causes of male infertility].
Аннотация на английскомСтатьяОбзорНазвание и аннотация: Перевод в очереди
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Ørstavik Karen Helene
Аннотация
BACKGROUND: Male infertility is due to genetic factors in 15% of cases. Identification of genetic causes is important for both prognosis and treatment. The article gives an overview of the most frequent genetic causes of male infertility.
MATERIAL AND METHOD: The article is based on literature retrieved through a search of Pubmed.
RESULTS AND INTERPRETATION: Klinefelter syndrome, 47, XXY, and microdeletion in AFZ (azoospermia factor) c on the long arm of the Y chromosome are the most common genetic causes of male infertility. Both are present in about 10-15% of males with azoospermia. Other important genetic causes are cystic fibrosis and androgen insensitivity syndrome. Men with azoospermia may become fathers using new reproductive techniques. The infertility may therefore be passed on to the next generation.
MATERIAL AND METHOD: The article is based on literature retrieved through a search of Pubmed.
RESULTS AND INTERPRETATION: Klinefelter syndrome, 47, XXY, and microdeletion in AFZ (azoospermia factor) c on the long arm of the Y chromosome are the most common genetic causes of male infertility. Both are present in about 10-15% of males with azoospermia. Other important genetic causes are cystic fibrosis and androgen insensitivity syndrome. Men with azoospermia may become fathers using new reproductive techniques. The infertility may therefore be passed on to the next generation.