Fertility and sterility · 2007
Birth of a healthy boy after fertilization of cryopreserved oocytes with cryopreserved testicular spermatozoa from a man with nonmosaic Klinefelter syndrome.
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Greco Ermanno, Iacobelli Marcello, Rienzi Laura, Fabris Giuseppe F Menchini, Tesorio Nicola, Tesarik Jan
Аннотация
OBJECTIVE: To report the first birth with frozen spermatozoa and frozen oocytes in a case of nonmosaic Klinefelter syndrome.
DESIGN: Case report.
SETTING: Private IVF clinics and a university hospital.
PATIENT(S): A 32-year-old woman and a 33-year-old man.
INTERVENTION(S): Testicular sperm extraction and cryopreservation, oocyte recovery and cryopreservation, intracytoplasmic sperm injection.
MAIN OUTCOME MEASURE(S): Assessment of fertilization and chromosomal analysis of newborn child.
RESULT(S): Three oocytes were injected and one embryo was obtained, resulting in the birth of a normal (46,XY) boy.
CONCLUSION(S): Cryopreserved spermatozoa from a patient with nonmosaic Klinefelter syndrome can form normal embryos even with cryopreserved oocytes.
DESIGN: Case report.
SETTING: Private IVF clinics and a university hospital.
PATIENT(S): A 32-year-old woman and a 33-year-old man.
INTERVENTION(S): Testicular sperm extraction and cryopreservation, oocyte recovery and cryopreservation, intracytoplasmic sperm injection.
MAIN OUTCOME MEASURE(S): Assessment of fertilization and chromosomal analysis of newborn child.
RESULT(S): Three oocytes were injected and one embryo was obtained, resulting in the birth of a normal (46,XY) boy.
CONCLUSION(S): Cryopreserved spermatozoa from a patient with nonmosaic Klinefelter syndrome can form normal embryos even with cryopreserved oocytes.