AGORA, a data- and biobank for birth defects and childhood cancer.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
van Rooij Iris A L M, van der Zanden Loes F M, Bongers Ernie M H F, Renkema Kirsten Y, Wijers Charlotte H W, Thonissen Michelle, Dokter Elisabeth M J, Marcelis Carlo L M, de Blaauw Ivo, Wijnen Marc H W A, Hoogerbrugge Peter M, Bokkerink Jos P M, Schreuder Michiel F, Koster-Kamphuis Linda, Cornelissen Elisabeth A M, Kapusta Livia, van Heijst Arno F J, Liem Kian D, de Gier Robert P E, Kuijpers-Jagtman Anne Marie, Admiraal Ronald J C, Bergé Stefaan J, van der Biezen Jan Jaap, Verdonck An, Vander Poorten Vincent, Hens Greet, Roosenboom Jasmien, Lilien Marc R, de Jong Tom P, Broens Paul, Wijnen Rene, Brooks Alice, Franke Barbara, Brunner Han G, Carels Carine E L, Knoers Nine V A M, Feitz Wout F J, Roeleveld Nel
Аннотация
METHODS: Children diagnosed with and/or treated for a structural birth defect or childhood cancer and their parents are invited to participate in the AGORA data- and biobank. Controls are recruited through random sampling from municipal registries. The parents receive questionnaires about demographics, family and pregnancy history, health status, prescribed medication, lifestyle, and occupational exposures before and during the index pregnancy. In addition, blood or saliva is collected from children and parents, while medical records are reviewed for diagnostic information.
RESULTS: So far, we have collected data from over 6,860 families (3,747 birth defects, 905 childhood cancers, and 2,208 controls). The types of birth defects vary widely and comprise malformations of the digestive, respiratory, and urogenital tracts as well as facial, cardiovascular, kidney, skeletal, and central nervous system anomalies. The most frequently occurring childhood cancer types are acute lymphatic leukemia, Hodgkin and non-Hodgkin lymphoma, Wilms' tumor, and brain and spinal cord tumors. Our genetic and/or epidemiologic studies have been focused on hypospadias, anorectal malformations, congenital anomalies of the kidney and urinary tract (CAKUT), and orofacial clefts.
CONCLUSION: The large AGORA data- and biobank offers great opportunities for investigating genetic and nongenetic risk factors for disorders in children and is open to collaborative initiatives. Birth Defects Research (Part A) 106:675-684, 2016. © 2016 Wiley Periodicals, Inc.