Fertility and sterility · 2010
In vitro fertilization surrogacy in rare coexisting Mayer-Rokitansky-Kuster-Hauser syndrome and triple X karyotype.
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Raziel Arieh, Friedler Shevach, Gidoni Yariv, Ben-ami Ido, Strassburger Deborah, Ron-El Raphael
Аннотация
OBJECTIVE: To report the responses to IVF surrogacy attempts in a female with a heretofore never described combination of Mayer-Rokitansky-Kuster-Hauser (MRHK) syndrome and triple X karyotype.
DESIGN: Case report.
SETTING: Reproductive unit of a university-affiliated medical center.
PATIENT(S): A 29-year-old female diagnosed as having both MRHK syndrome and a triple X (47XXX) karyotype.
INTERVENTION(S): Five cycles of IVF surrogacy.
MAIN OUTCOME MEASURE(S): Recovery of oocytes after controlled ovarian stimulation.
RESULT(S): A maximum of five oocytes were retrieved by percutaneous abdominal aspiration of a single subcostal left ovary. After five unsuccessful IVF trials due to low ovarian response attributed to her coexisting MRHK syndrome and triple X karyotype, the patient's choice was oocyte donation.
CONCLUSION(S): An abnormal karyotype can coexist with MRKH syndrome, albeit very rarely, and probably accounts for a low ovarian response to attempts to achieve IVF surrogacy.
DESIGN: Case report.
SETTING: Reproductive unit of a university-affiliated medical center.
PATIENT(S): A 29-year-old female diagnosed as having both MRHK syndrome and a triple X (47XXX) karyotype.
INTERVENTION(S): Five cycles of IVF surrogacy.
MAIN OUTCOME MEASURE(S): Recovery of oocytes after controlled ovarian stimulation.
RESULT(S): A maximum of five oocytes were retrieved by percutaneous abdominal aspiration of a single subcostal left ovary. After five unsuccessful IVF trials due to low ovarian response attributed to her coexisting MRHK syndrome and triple X karyotype, the patient's choice was oocyte donation.
CONCLUSION(S): An abnormal karyotype can coexist with MRKH syndrome, albeit very rarely, and probably accounts for a low ovarian response to attempts to achieve IVF surrogacy.
Предметные рубрики MeSH
46, XX Disorders of Sex DevelopmentAbnormalities, MultipleAdultChromosomes, Human, XCongenital AbnormalitiesFemaleFertilization in VitroHumansInfertility, FemaleKaryotypingKidneyMullerian DuctsPregnancySex Chromosome AberrationsSex Chromosome Disorders of Sex DevelopmentSomitesSpineGestational CarriersTrisomyUterusVagina