Association between two single nucleotide polymorphisms of interleukin-27 gene and increased cryptorchidism risk.

Growing evidences have suggested the association between interleukin-27 and cryptorchidism. We aimed to investigate the relationship between IL-27 polymorphisms and cryptorchidism susceptibility. A total of 519 males were enrolled in a case-control study (150 cases and 369 normal subjects). The variants were discriminated using polymerase chain reaction-restriction fragment length polymorphism methods. The proportions of the major allele for rs153109 and rs17855750 were A and T with frequencies of 0.56 and 0.85 in cases and 0.51 and 0.91 in controls respectively (P values = 0.002, P value = 0.002). The heterozygous genotype of rs153109 and 17855750 was A/G and T/G with frequencies of 0.62 and 0.25 in cases and 0.39 and 0.17 in controls respectively (P values <0.001, P values <0.001). The A allele and A/G genotype of rs153109 polymorphisms contribute to increase cryptorchidism susceptibility, and G allele and T/G genotype of rs17855750 also contribute to increase cryptorchidism susceptibility, which implies that these allele and genotypes may be risk factors for the development of cryptorchidism.