Journal of psychiatric research · 2025
Psychiatric comorbidity and in-hospital mortality in patients hospitalized for physical conditions in Germany.
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Kostev Karel, Landré Benjamin, Yon Dong Keon, Haro Josep Maria, Gyasi Razak M, Hajek André, Jacob Louis
Аннотация
OBJECTIVE: To investigate the association between psychiatric comorbidity and in-hospital mortality in patients hospitalized for physical conditions in Germany.
METHODS: This retrospective study used data from the hospital database of IQVIA (Frankfurt, Germany). Adults with a psychiatric disorder as a secondary diagnosis at hospital admission were matched (1:3) to those without a psychiatric disorder using a propensity score based on age, sex, hospital department, and primary diagnosis. Diagnoses of psychiatric and physical disorders relied on the ICD-10 classification. Associations between psychiatric comorbidity and in-hospital mortality were studied using logistic regression.
RESULTS: There were 36,796 patients with (mean [SD] age 66.2 [14.7] years; 53.4% men) and 110,388 patients without psychiatric comorbidity included in the study (mean [SD] age 66.1 [15.1] years; 51.9% men). Overall, no statistical association was observed between psychiatric comorbidity and in-hospital mortality (OR = 1.00, 95% CI = 0.95-1.05). However, there was a positive and significant relationship in people aged ≤70 years and men, whereas a negative association was observed for those aged >80 years and women.
CONCLUSIONS: Psychiatric comorbidity was associated with increased in-hospital mortality in patients aged ≤70 years and men in hospitals in Germany. Further research is warranted to corroborate these findings in other countries.
METHODS: This retrospective study used data from the hospital database of IQVIA (Frankfurt, Germany). Adults with a psychiatric disorder as a secondary diagnosis at hospital admission were matched (1:3) to those without a psychiatric disorder using a propensity score based on age, sex, hospital department, and primary diagnosis. Diagnoses of psychiatric and physical disorders relied on the ICD-10 classification. Associations between psychiatric comorbidity and in-hospital mortality were studied using logistic regression.
RESULTS: There were 36,796 patients with (mean [SD] age 66.2 [14.7] years; 53.4% men) and 110,388 patients without psychiatric comorbidity included in the study (mean [SD] age 66.1 [15.1] years; 51.9% men). Overall, no statistical association was observed between psychiatric comorbidity and in-hospital mortality (OR = 1.00, 95% CI = 0.95-1.05). However, there was a positive and significant relationship in people aged ≤70 years and men, whereas a negative association was observed for those aged >80 years and women.
CONCLUSIONS: Psychiatric comorbidity was associated with increased in-hospital mortality in patients aged ≤70 years and men in hospitals in Germany. Further research is warranted to corroborate these findings in other countries.