Low expression of miR-126 constitutes a risk factor for perioperative respiratory adverse events among pediatric patients under general anesthesia.

AIM: This study aims to investigate the diagnostic value of miR-126 in Perioperative respiratory adverse events (PRAEs).

METHODS

This study included 228 pediatric patients undergoing anesthesia and surgery, who were divided into two groups based on the occurrence of PRAEs. RT-qPCR was used to detect miR-126 levels, the CCK-8 assay was employed to evaluate cell proliferation capacity, and ELISA kits were utilized to measure TNF-α, IL-6, and IL-13 concentrations. The diagnostic value of miR-126 was assessed through receiver operating characteristic curve analysis.

RESULTS

miR-126 is significantly downregulated in the serum of children with PAREs. Low expression of miR-126 is one of the risk factors for PRAEs occurrence. miR-126 level shows a negative correlation with the inflammatory levels in children with PRAEs. Overexpression of miR-126 promotes cell proliferation activity.

CONCLUSION

miR-126 may contribute to the suppression of PRAEs by regulating proliferation and inflammatory responses in BEAS-2B cells and may serve as a diagnostic biomarker.