Journal of cancer research and therapeutics · 2019
Effects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat model.
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Yildiz Hasan, Kalipci Erkan, Oztas Haydar, Yildiz Deniz
Аннотация
AIM: The effect of acetylsalicylic acid (ASA) on thiol levels was studied in a rat model of azaserine carcinogenesis.
MATERIALS AND METHODS: ASA and azaserine were applied to the animals to research changes in cellular sulfhydryl (-SH) content and variations in free and protein-bound molecules containing the -SH group. Such effects in rats injected with azaserine were investigated at low (200 ppm) and high (400 ppm) concentrations of ASA over a relatively short (6 months) and a relatively long (12 months) period.
RESULTS: Changes in the hepatic, pancreatic, and renal -SH contents were also determined.
CONCLUSION: Compared to the other tissues studied, the liver contained the highest levels of both free and protein-bound -SH.
MATERIALS AND METHODS: ASA and azaserine were applied to the animals to research changes in cellular sulfhydryl (-SH) content and variations in free and protein-bound molecules containing the -SH group. Such effects in rats injected with azaserine were investigated at low (200 ppm) and high (400 ppm) concentrations of ASA over a relatively short (6 months) and a relatively long (12 months) period.
RESULTS: Changes in the hepatic, pancreatic, and renal -SH contents were also determined.
CONCLUSION: Compared to the other tissues studied, the liver contained the highest levels of both free and protein-bound -SH.