Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Payne Amanda B, Gilani Zunera, Godfred-Cato Shana, Belay Ermias D, Feldstein Leora R, Patel Manish M, Randolph Adrienne G, Newhams Margaret, Thomas Deepam, Magleby Reed, Hsu Katherine, Burns Meagan, Dufort Elizabeth, Maxted Angie, Pietrowski Michael, Longenberger Allison, Bidol Sally, Henderson Justin, Sosa Lynn, Edmundson Alexandra, Tobin-D'Angelo Melissa, Edison Laura, Heidemann Sabrina, Singh Aalok R, Giuliano John S, Kleinman Lawrence C, Tarquinio Keiko M, Walsh Rowan F, Fitzgerald Julie C, Clouser Katharine N, Gertz Shira J, Carroll Ryan W, Carroll Christopher L, Hoots Brooke E, Reed Carrie, Dahlgren F Scott, Oster Matthew E, Pierce Timmy J, Curns Aaron T, Langley Gayle E, Campbell Angela P, MIS-C Incidence Authorship Group, Balachandran Neha, Murray Thomas S, Burkholder Cole, Brancard Troy, Lifshitz Jenna, Leach Dylan, Charpie Ian, Tice Cory, Coffin Susan E, Perella Dana, Jones Kaitlin, Marohn Kimberly L, Yager Phoebe H, Fernandes Neil D, Flori Heidi R, Koncicki Monica L, Walker Karen S, Di Pentima Maria Cecilia, Li Simon, Horwitz Steven M, Gaur Sunanda, Coffey Dennis C, Harwayne-Gidansky Ilana, Hymes Saul R, Thomas Neal J, Ackerman Kate G, Cholette Jill M
Аннотация
OBJECTIVE: To estimate population-based MIS-C incidence per 1 000 000 person-months and to estimate MIS-C incidence per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years.
DESIGN, SETTING, AND PARTICIPANTS: This cohort study used enhanced surveillance data to identify persons with MIS-C during April to June 2020, in 7 jurisdictions reporting to both the Centers for Disease Control and Prevention national surveillance and to Overcoming COVID-19, a multicenter MIS-C study. Denominators for population-based estimates were derived from census estimates; denominators for incidence per 1 000 000 SARS-CoV-2 infections were estimated by applying published age- and month-specific multipliers accounting for underdetection of reported COVID-19 case counts. Jurisdictions included Connecticut, Georgia, Massachusetts, Michigan, New Jersey, New York (excluding New York City), and Pennsylvania. Data analyses were conducted from August to December 2020.
EXPOSURES: Race/ethnicity, sex, and age group (ie, ≤5, 6-10, 11-15, and 16-20 years).
MAIN OUTCOMES AND MEASURES: Overall and stratum-specific adjusted estimated MIS-C incidence per 1 000 000 person-months and per 1 000 000 SARS-CoV-2 infections.
RESULTS: In the 7 jurisdictions examined, 248 persons with MIS-C were reported (median [interquartile range] age, 8 [4-13] years; 133 [53.6%] male; 96 persons [38.7%] were Hispanic or Latino; 75 persons [30.2%] were Black). The incidence of MIS-C per 1 000 000 person-months was 5.1 (95% CI, 4.5-5.8) persons. Compared with White persons, incidence per 1 000 000 person-months was higher among Black persons (adjusted incidence rate ratio [aIRR], 9.26 [95% CI, 6.15-13.93]), Hispanic or Latino persons (aIRR, 8.92 [95% CI, 6.00-13.26]), and Asian or Pacific Islander (aIRR, 2.94 [95% CI, 1.49-5.82]) persons. MIS-C incidence per 1 000 000 SARS-CoV-2 infections was 316 (95% CI, 278-357) persons and was higher among Black (aIRR, 5.62 [95% CI, 3.68-8.60]), Hispanic or Latino (aIRR, 4.26 [95% CI, 2.85-6.38]), and Asian or Pacific Islander persons (aIRR, 2.88 [95% CI, 1.42-5.83]) compared with White persons. For both analyses, incidence was highest among children aged 5 years or younger (4.9 [95% CI, 3.7-6.6] children per 1 000 000 person-months) and children aged 6 to 10 years (6.3 [95% CI, 4.8-8.3] children per 1 000 000 person-months).
CONCLUSIONS AND RELEVANCE: In this cohort study, MIS-C was a rare complication associated with SARS-CoV-2 infection. Estimates for population-based incidence and incidence among persons with infection were higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons. Further study is needed to understand variability by race/ethnicity and age group.