Imaging Evaluation of Pediatric Supratentorial Tumors: Pearls and Pitfalls.

Pediatric supratentorial tumors are almost always primary brain tumors. They are defined by a relatively short list of diagnoses that can be broadly divided into tumors with high-grade and low-grade features, intraventricular lesions, and other rare tumors. The differential diagnosis can be further narrowed depending on age at presentation and particular imaging features. Treatment in most cases is surgical resection and may be followed by adjuvant therapy. Many tumors, such as high-grade glioma, ependymoma, and atypical teratoid rhabdoid tumor, are associated with specific genetic mutations that determine diagnosis and prognosis. ©RSNA, 2026 Supplemental material is available for this article.