Assessment of variables associated with prolonged admission duration in children with Mycoplasma pneumoniae pneumonia.
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Sung Myongsoon, Roh Eui Jeong, Lee Eun Sil, Lee Ji Young, Kim Hyo-Bin, Ahn Youngmin, Eun Byung Wook, Kim Ja Kyoung, Kim Hyoung Young, Jung Sung-Su, Kim Minji, Kang Eun Kyeong, Yang Eun-Ae, Lee Soo Jin, Park Yang, Seo Ju-Hee, Lee Eun, Yang Eun Seok, Cho Hyung Min, Shin Meeyong, Chung Hai Lee, Jang Yoon Young, Choi Bong Seok, Kim Hyeona, Jung Jin-A, You Seung Taek, Lee Mi-Hee, Kim Jin Tack, Kim Bong Seong, Hwang Yoon Ha, Shim Jung Yeon, Yang Hyeon-Jong, Han Man Yong, Yew Hae Young, Kim Dong Hyeok, Jeong Sang Oun, Whang Kyujam, Lee Eunjoo, Jeon You Hoon, Chung Eun Hee
Аннотация
METHODS: A prospective multicenter study was conducted in 1063 children <18 years old in July 2018-June 2020. The 454 had a positive M. pneumoniae polymerase chain reaction assay.
RESULTS: Most subjects had MRMP (78.4%), and all mutated strains had the A2063G transition. We defined MRMP* (n = 285) as MRMP pneumonia requiring admission and MSMP* (n = 72) as MSMP pneumonia requiring admission. Patients with MRMP pneumonia were older, more likely to have segmental/lobar pneumonia, and had more febrile days than those with MSMP pneumonia. C-reactive protein (CRP), lactate dehydrogenase (LDH), and percentage neutrophils were more strongly associated with MRMP* than MSMP* groups. Percentage neutrophils, CRP, and alanine aminotransferase significantly changed between admission and follow-up measurements in patients with MRMP* (P < 0.05). The duration of admission positively correlated with the number of febrile days after initiation of antibiotic medication and laboratory variables (white blood cell count, CRP, and aspartate aminotransferase [AST]) (P < 0.05). Random forest analysis indicated that the number of febrile days after initiation of antibiotic medication, AST, and percentage neutrophils at admission was over five.
CONCLUSIONS: This study indicated that children with M. pneumoniae pneumonia with a higher number of febrile days after initiation of antibiotic medication, AST, and percentage neutrophils at admission were more likely to have prolonged admission duration.