Cerebrospinal fluid dynamics and cerebrospinal fluid infusion in children. Part I: A revised method and a review.

In the study of cerebrospinal fluid dynamics in children with macrocephaly, the lumbar CSF infusion technique has always been used. Previous studies showed, that the regulation of cerebrospinal fluid dynamics are mainly determined by Pressure-Volume Index (PVI) and outflow resistance (Ro). Recent studies have shown, that the relationship between pressure and volume is mono exponential with a constant. This result suggests a third parameter c. PVI, Ro and c were determined with a combination of bolusmethod and a constant flow infusion.