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DOI 10.1002/alz.14343

Медицинская библиотека · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024

Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.

Peterson Amalia, Sathe Aditi, Zaras Dimitrios, Yang Yisu, Durant Alaina, Deters Kacie D, Shashikumar Niranjana, Pechman Kimberly R, Kim Michael E, Gao Chenyu, Mohd Khairi Nazirah, Li Zhiyuan, Yao Tianyuan, Huo Yuankai, Dumitrescu Logan, Gifford Katherine A, Wilson Jo Ellen, Cambronero Francis E, Risacher Shannon L, Beason-Held Lori L, An Yang, Arfanakis Konstantinos, Erus Guray, Davatzikos Christos, Tosun Duygu, Toga Arthur W, Thompson Paul M, Mormino Elizabeth C, Habes Mohamad, Wang Di, Zhang Panpan, Schilling Kurt, Alzheimer's Disease Neuroimaging Initiative (ADNI), BIOCARD Study Team, Alzheimer's Disease Sequencing Project (ADSP), Albert Marilyn, Kukull Walter, Biber Sarah A, Landman Bennett A, Johnson Sterling C, Schneider Julie, Barnes Lisa L, Bennett David A, Jefferson Angela L, Resnick Susan M, Saykin Andrew J, Hohman Timothy J, Archer Derek B

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Аннотация

INTRODUCTION

The effects of sex and apolipoprotein E (APOE)-Alzheimer's disease (AD) risk factors-on white matter microstructure are not well characterized.

METHODS

Diffusion magnetic resonance imaging data from nine well-established longitudinal cohorts of aging were free water (FW)-corrected and harmonized. This dataset included 4741 participants (age = 73.06 ± 9.75) with 9671 imaging sessions over time. FW and FW-corrected fractional anisotropy (FAFWcorr) were used to assess differences in white matter microstructure by sex and APOE ε4 carrier status.

RESULTS

Sex differences in FAFWcorr in projection tracts and APOE ε4 differences in FW limbic and occipital transcallosal tracts were most pronounced.

DISCUSSION: There are prominent differences in white matter microstructure by sex and APOE ε4 carrier status. This work adds to our understanding of disparities in AD. Additional work to understand the etiology of these differences is warranted.

HIGHLIGHTS: Sex and apolipoprotein E (APOE) ε4 carrier status relate to white matter microstructural integrity. Females generally have lower free water-corrected fractional anisotropy compared to males. APOE ε4 carriers tended to have higher free water than non-carriers.

Для цитирования: Peterson Amalia, Sathe Aditi, Zaras Dimitrios, Yang Yisu, Durant Alaina, Deters Kacie D, Shashikumar Niranjana, Pechman Kimberly R, Kim Michael E, Gao Chenyu, Mohd Khairi Nazirah, Li Zhiyuan, Yao Tianyuan, Huo Yuankai, Dumitrescu Logan, Gifford Katherine A, Wilson Jo Ellen, Cambronero Francis E, Risacher Shannon L, Beason-Held Lori L, An Yang, Arfanakis Konstantinos, Erus Guray, Davatzikos Christos, Tosun Duygu, Toga Arthur W, Thompson Paul M, Mormino Elizabeth C, Habes Mohamad, Wang Di, Zhang Panpan, Schilling Kurt, Alzheimer's Disease Neuroimaging Initiative (ADNI), BIOCARD Study Team, Alzheimer's Disease Sequencing Project (ADSP), Albert Marilyn, Kukull Walter, Biber Sarah A, Landman Bennett A, Johnson Sterling C, Schneider Julie, Barnes Lisa L, Bennett David A, Jefferson Angela L, Resnick Susan M, Saykin Andrew J, Hohman Timothy J, Archer Derek B. Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. DOI: 10.1002/alz.14343.

Предметные рубрики MeSH

HumansAlzheimer DiseaseFemaleMaleWhite MatterAgedApolipoprotein E4Longitudinal StudiesAgingAllelesDiffusion Magnetic Resonance ImagingSex CharacteristicsAged, 80 and overCohort StudiesAnisotropyBrain
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