Resuscitation · 2026
Symptoms of anxiety and depression after out-of-hospital cardiac arrest: an exploratory dyadic analysis of survivors and their cohabiting spouses or partners from the BOX trial.
СтатьяНаблюдательное исследованиеМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Bekker-Jensen Ditte, Kjærgaard Jesper, Schmidt Henrik, Dababneh Julie T, Fuglsbjerg Cecilie, Grand Johannes, Hassager Christian, Meyer Martin A S, Mølstrøm Simon, Møller Jacob E, Borregaard Britt
Аннотация
AIM: The objectives were to: (i) compare symptoms of anxiety and depression between survivors and cohabiting spouses/partners, and (ii) investigate characteristics associated with higher scores of anxiety and depression in both parts, respectively.
METHODS: This observational exploratory substudy used three-month follow-up data from the Blood Pressure and Oxygenation Targets after Cardiac Arrest (BOX)-trial, restricted to cohabiting survivor-partner dyads. Symptoms of anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS-A anxiety, HADS-D depression). Paired comparisons were used to examine differences within the dyad, and multivariable linear regression models applied separately for survivors and spouses/partners to investigate associations between characteristics and symptom burden, reported as β with 95% confidence intervals (CI).
RESULTS: Among 321 eligible OHCA survivors, 200 survivor-partner dyads were included. Median HADS-A scores were 4 (IQR 1-7) in survivors and 5 (IQR 1-8) in spouses/partners (p = 0.107). Median HADS-D scores were 1 (IQR 0-4) and 1 (IQR 0-3), respectively (p = 0.290). In adjusted regression analyses among survivors, higher age was associated with lower scores of HADS-A (β -0.065, 95% CI -0.125; -0.025; p = 0.012) and HADS-D (β -0.040, 95% CI -0.090; -0.00; p = 0.037). In sensitivity analyses, poorer self-rated health was associated with higher scores of HADS-A and HADS-D in both parts, and poorer survivor self-rated health was associated with higher scores of HADS-D among spouses/partners.
CONCLUSION: Symptoms of anxiety and depression did not differ in survivors and their spouse/partners. Higher age was associated with lower scores of anxiety and depression among survivors, and poorer self-rated health with higher symptom-scores in both.
METHODS: This observational exploratory substudy used three-month follow-up data from the Blood Pressure and Oxygenation Targets after Cardiac Arrest (BOX)-trial, restricted to cohabiting survivor-partner dyads. Symptoms of anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS-A anxiety, HADS-D depression). Paired comparisons were used to examine differences within the dyad, and multivariable linear regression models applied separately for survivors and spouses/partners to investigate associations between characteristics and symptom burden, reported as β with 95% confidence intervals (CI).
RESULTS: Among 321 eligible OHCA survivors, 200 survivor-partner dyads were included. Median HADS-A scores were 4 (IQR 1-7) in survivors and 5 (IQR 1-8) in spouses/partners (p = 0.107). Median HADS-D scores were 1 (IQR 0-4) and 1 (IQR 0-3), respectively (p = 0.290). In adjusted regression analyses among survivors, higher age was associated with lower scores of HADS-A (β -0.065, 95% CI -0.125; -0.025; p = 0.012) and HADS-D (β -0.040, 95% CI -0.090; -0.00; p = 0.037). In sensitivity analyses, poorer self-rated health was associated with higher scores of HADS-A and HADS-D in both parts, and poorer survivor self-rated health was associated with higher scores of HADS-D among spouses/partners.
CONCLUSION: Symptoms of anxiety and depression did not differ in survivors and their spouse/partners. Higher age was associated with lower scores of anxiety and depression among survivors, and poorer self-rated health with higher symptom-scores in both.