Internal medicine (Tokyo, Japan) · 2022
A Woman with Rheumatoid Arthritis Who Successfully Delivered a Healthy Child with Continuous Administration of Sarilumab Throughout Pregnancy.
СтатьяНазвание и аннотация: Перевод в очереди
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Mizutani Satoshi, Okunishi Yuki, Tamada Tatsuya, Tanaka Hiroyuki, Ito Yuhei, Yamamoto Yoshiki, Kitamura Asa, Tanaka Hiroaki, Ikeda Tomoaki, Nakajima Ayako
Аннотация
We herein report a patient with rheumatoid arthritis (RA) who successfully delivered a healthy child with continuous administration of sarilumab throughout pregnancy. She delivered her first child, a healthy boy, following in vitro fertilization-embryo transfer (IVF-ET) while using etanercept and low-dose prednisolone. Disease activity persisted after delivery, so etanercept was switched to sarilumab. She became pregnant by IVF-ET again. Because RA was still active, sarilumab was continued during pregnancy. She delivered a healthy girl at the 38th week of gestation by Caesarean section. No abnormalities were detected at or within 6 months after birth. Sarilumab was safe and effective in this pregnant woman with RA.