[Effects of human papillomavirus infection on pregnant women and chorionic trophoblasts].

OBJECTIVE

To evaluate the effects of human papilloma virus (HPV) infection on pregnant women and chorionic trophoblasts.

METHODS

The morphological characters were observed from 62 pregnant women with codyloma acuminatum during the first and second trimester. In situ hybridization (ISH) was performed to detect HPV 6/11 in chorionic villi of all these cases. In 10 cases, ISH was also performed in condyloma acuminatum of vulva, vaginal and cervix. In 10 cases HPV 6/11 was detected by polymerase chain reaction (PCR) in chorionic villi as well.

RESULTS

The lesions condyloma acuminatum developed rapidly during pregnancy. Multiple lesions were found usually, and the gross appearances and histological features were more typical. Using ISH and PCR to detect HPV 6/11-DNA in chorionic villi all showed negative. 8 of 10 cases were positive in condyloma acuminatum sites by ISH.

CONCLUSIONS

HPV infection does not make vertical transmission during first and second trimester. It does not increase the potential risk for the fetus.