Fertility and sterility · 2008
CYP11A1 and CYP17 promoter polymorphisms associate with hyperandrogenemia in polycystic ovary syndrome.
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Pusalkar Madhavi, Meherji Pervin, Gokral Jyotsna, Chinnaraj Saravanan, Maitra Anurupa
Аннотация
OBJECTIVE: To analyze promoter regions of CYP11A1 and CYP17 for putative variations in a defined group of women with polycystic ovary syndrome (PCOS) and to study their association with androgen levels.
DESIGN: Retrospective study.
SETTING: A secondary referral center for infertility at National Institute for Research in Reproductive Health, Mumbai, India.
PATIENT(S): One hundred women whose condition was diagnosed on the basis of the Rotterdam consensus were compared against 100 age-matched controls.
INTERVENTION(S): A single sample of blood was collected after overnight fast on day 3 of the menstrual cycle.
MAIN OUTCOME MEASURE(S): Plasma levels of T, androstenedione, 17alpha-hydroxyprogesterone, and DHEAS and nucleotide sequence of promoter regions of CYP11A1 and CYP17 genes.
RESULT(S): Polymorphisms in promoter regions of the two key androgen-regulating genes, CYP11A1 and CYP17, were found to be significantly associated with T levels in the cohort of well-characterized PCOS cases as compared with controls. The significance was greater in the PCOS cases with both the polymorphisms.
CONCLUSION(S): Our study carried out in a defined group of Indian women with PCOS suggests for the first time an individual, as well as combined, association of polymorphisms in CYP11A1 and CYP17 promoters with T levels.
DESIGN: Retrospective study.
SETTING: A secondary referral center for infertility at National Institute for Research in Reproductive Health, Mumbai, India.
PATIENT(S): One hundred women whose condition was diagnosed on the basis of the Rotterdam consensus were compared against 100 age-matched controls.
INTERVENTION(S): A single sample of blood was collected after overnight fast on day 3 of the menstrual cycle.
MAIN OUTCOME MEASURE(S): Plasma levels of T, androstenedione, 17alpha-hydroxyprogesterone, and DHEAS and nucleotide sequence of promoter regions of CYP11A1 and CYP17 genes.
RESULT(S): Polymorphisms in promoter regions of the two key androgen-regulating genes, CYP11A1 and CYP17, were found to be significantly associated with T levels in the cohort of well-characterized PCOS cases as compared with controls. The significance was greater in the PCOS cases with both the polymorphisms.
CONCLUSION(S): Our study carried out in a defined group of Indian women with PCOS suggests for the first time an individual, as well as combined, association of polymorphisms in CYP11A1 and CYP17 promoters with T levels.
Предметные рубрики MeSH
Cholesterol Side-Chain Cleavage EnzymeComorbidityFemaleGenetic Predisposition to DiseaseHumansHydroxysteroid DehydrogenasesHyperandrogenismIncidenceIndiaPolycystic Ovary SyndromePolymorphism, Single NucleotidePromoter Regions, GeneticRisk AssessmentRisk FactorsSteroid 17-alpha-HydroxylaseYoung Adult