La Revue de medecine interne · 2025
[Gastrointestinal hemorrhage due to a probable warfarin/oseltamivir drug interaction: A case report].
СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод в очереди
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Abisror Jonathan, Asgari Roya, de Baynast Quentin, Le Beller Christine, Karam Nicole, Sabatier Brigitte, Caruba Thibaut
Аннотация
INTRODUCTION: Bleeding while on vitamin K antagonist therapy is one of the main causes of iatrogenic hospitalization. There are few reports of a drug-drug interactions resulting in a serious bleeding complications between warfarin and oseltamivir.
CASE REPORT: We report the case of a 64-year-old woman hospitalized with anemia. She was on warfarin for mechanical heart valve prostheses (usual international normalized ratio, INR: 2.5-3.5) and had moderate renal insufficiency. Treatment with oseltamivir for influenza was introduced, leading to a rapid increase in the INR value within less than a week and a recurrence of digestive bleeding. Symptomatic management (antagonization with vitamin K and prothrombin complex concentrate) led to correction of the overdose.
CONCLUSION: When oseltamivir is introduced in a patient receiving warfarin, we suggest close monitoring of the INR, especially in the case of renal insufficiency, from initiation to the elimination of the oseltamivir (3 days after discontinuation).
CASE REPORT: We report the case of a 64-year-old woman hospitalized with anemia. She was on warfarin for mechanical heart valve prostheses (usual international normalized ratio, INR: 2.5-3.5) and had moderate renal insufficiency. Treatment with oseltamivir for influenza was introduced, leading to a rapid increase in the INR value within less than a week and a recurrence of digestive bleeding. Symptomatic management (antagonization with vitamin K and prothrombin complex concentrate) led to correction of the overdose.
CONCLUSION: When oseltamivir is introduced in a patient receiving warfarin, we suggest close monitoring of the INR, especially in the case of renal insufficiency, from initiation to the elimination of the oseltamivir (3 days after discontinuation).