Boosted wound healing and anticancer potential of polymer functionalized cerium oxide nanomaterials.

BACKGROUND

Wound recovery is an important part of treatment to prevent internal organelles from possible exposure to outer pathogens. In recent years, different therapies have been reported to enhance the natural wound healing process with faster and more effective tissue repair.

METHOD: The hydrothermal method has been endeavored to synthesize eco-friendly and cost-effective polymer (polyethylene glycol (PEG) and chitosan) functionalized cerium oxide nanoparticles (CeO2 NPs). Wound healing potential was studied on Chorioallantoic Membrane Assay and G. domesticus wheras anticancer studies were conducted against HuH-7.0 (hepatic cancer cell line).

RESULTS

Wound healing properties are studied initially through CAM assay which shows vein growth with chitosan-functionalized CeO2 NPs. The topical wound healing studies on G. domesticus show speedy recovery and quicker completion of the skin remodeling phase, observed through the quality of the recovered skin. Additionally, PEGylation has promoted the anticancer potential of CeO2 NPs against HuH-7.0 (hepatic cancer cell line) and the IC50 value is 37.89 μg/mL.

CONCLUSION

The results show that PEG and chitosan coating have enhanced the therapeutic prospects of CeO2 NPs.