Pediatric neurology · 2025
Effects of Arrhythmias on the Mortality and Morbidity in Pediatric Patients With Seizure Disorders.
СтатьяНазвание и аннотация: Перевод в очереди
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Cong Catherine Y, Ghimire Laxmi V, Liang Shannon N, Torabyan Zareh, El-Rahi Hiba
Аннотация
BACKGROUND: Seizures, a potentially fatal disorder, share similar mechanisms of action as arrhythmias, as both result from irregular electrical activity. Although cardiac arrhythmias contribute to sudden unexpected death in epilepsy, their impact on seizure disorders remains unclear. This study examines whether cardiac arrhythmias increase the mortality and morbidity in children with seizure disorders and explores the potential benefits of incorporating cardiac evaluations into the routine evaluation and management of patients with new-onset epilepsy.
METHODS: This study used the National Inpatient Sample from 2016 to 2020. Patients aged <21 years admitted with seizures were included, whereas those transferred in and out of the hospital were excluded. A logistic regression model was used to calculate the mortality in patients with seizures with tachyarrhythmias.
RESULTS: The overall in-hospital mortality for those with seizure disorders was 1.6%. The rate of mortality was much higher in children with seizures with concomitant tachyarrhythmias versus those without arrhythmias, 8.8% (n = 12,030) vs 1.5% (n = 12,320), P < 0.001. The length of stay was longer in the children with seizure disorders with coexisting arrhythmias versus those without arrhythmias, 5 (interquartile range [IQR] 2-12) vs 3 (IQR 1-5), P < 0.001. The logistic regression model also showed that tachyarrhythmias were associated with an increased mortality rate, adjusted odds ratio = 2.60 (confidence interval [CI] 2.20-3.07), P < 0.001.
CONCLUSIONS: Children with seizure disorders who have concomitant tachyarrhythmias have higher in-hospital mortality, increased morbidities, and prolonged hospitalization.
METHODS: This study used the National Inpatient Sample from 2016 to 2020. Patients aged <21 years admitted with seizures were included, whereas those transferred in and out of the hospital were excluded. A logistic regression model was used to calculate the mortality in patients with seizures with tachyarrhythmias.
RESULTS: The overall in-hospital mortality for those with seizure disorders was 1.6%. The rate of mortality was much higher in children with seizures with concomitant tachyarrhythmias versus those without arrhythmias, 8.8% (n = 12,030) vs 1.5% (n = 12,320), P < 0.001. The length of stay was longer in the children with seizure disorders with coexisting arrhythmias versus those without arrhythmias, 5 (interquartile range [IQR] 2-12) vs 3 (IQR 1-5), P < 0.001. The logistic regression model also showed that tachyarrhythmias were associated with an increased mortality rate, adjusted odds ratio = 2.60 (confidence interval [CI] 2.20-3.07), P < 0.001.
CONCLUSIONS: Children with seizure disorders who have concomitant tachyarrhythmias have higher in-hospital mortality, increased morbidities, and prolonged hospitalization.