Malignant transformation of condyloma acuminatum: report of a case.

Condyloma acuminatum is a benign warty lesion, whose malignant change is rarely seen. A 69-year-old woman with a large vulvar condyloma acuminatum, which she had had for about 14 years, underwent a vulvectomy, and a malignant component to the lesion was found unexpectedly. The continuity from a benign to a malignant lesion was evident in the histopathologic examination. Infection with human papillomavirus type 6 was documented by DNA hybridization. The use of a one-step reverse dot blot hybridization with nonisotope DNA probe in this case was convenient and is recommended.