[Incidence of human papillomavirus types 31, 33 and 35 in cervix intra-epithelial neoplasms].

206 patients with cervical intraepithelial neoplasia (CIN) were examined at the Department of Gynaecology and Obstetrics of the University of Tübingen for genital infections with human papilloma viruses (HPV) using DNA-hybridisation. 1. The HPV-type-groups 31/33/35 and 16/18 occurred with approx. the same frequency. 2. Significantly more potentially reversible changes (CIN I.-II.) were associated with HPV types 31, 33 and 35 than with HPV-types 16 and 18, which were found more often in CIN III. (P less than 0.02). 3. In 37.5% of the infections established by DNA-hybridisation, the morphological criterion "koilocytosis" was not detected. DNA-hybridisation is a powerful tool in the differentiation of CIN. The sensitivity of this method is greater than that of morphological HPV, diagnostics.