[Human papillomavirus infection and carcinogenesis of cancer of the uterine cervix. I. Pathomorphology of 357 cervical tissues].

Human papillomavirus (HPV) infection in the cervix was studied by pathomorphology for the first time in China according to Meisels and Fortin's criteria. Cervical condyloma was found in 257 out of 357 (71.99%) cervical tissues. 141 were simple condyloma, 50 dysplasia with condyloma and 66 carcinoma with condyloma. A zone of continuous transformation was observed between the condyloma and dysplasia or carcinoma. 141 simple condylomas were initially diagnosed as chronic cervicitis in 94 (66.67%) and as dysplasia in 29 (20.57%). The pathomorphologic features of condyloma have not been fully recognized before. In carcinogenesis of the cervical carcinoma, the fact that condyloma associated becomes severer in extent but less in incidence, conforms well to Meisels' view that condyloma is the precursor of carcinoma in situ. It is suggested that HPV infection is closely related to cervical carcinoma.