Association of condylomas with intraepithelial and microinvasive cervical neoplasia: histopathology of conization and hysterectomy specimens.

The tissues for 110 patients who received conization and/or hysterectomy following colposcopic evaluation for abnormal Pap smears were evaluated in a blind, retrospective fashion. The patients were grouped as condyloma only, dysplasia, carcinoma in situ, and microinvasion. Special note was taken of the presence of condyloma in those patients with dysplasia or greater. The mean age for each group was determined, and the significance of the differences between groups was assessed using Student's t test. Eighty-three (75%) patients showed evidence of condyloma in at least one section. The mean age of 33.0 years for this group was significantly lower (p less than 0.01). Despite the possibility that condylomas may represent a venereal infection unrelated to carcinogenesis, the association of condylomas and cervical intraepithelial neoplasia is strong. The findings in this study are consistent with the hypothesis that some forms of dysplasia represent a virally transformed epithelium.