Functions of alpha-melanotropin and other opiomelanocortin peptides in labour, intrauterine growth and brain development.

In a number of animals and in humans, factors from the fetal hypothalamus function in intrauterine growth, in labour and in brain development. Peptides of the opiomelanocortin family are produced by the pituitary, brain and placenta and are probably involved in these developmental processes. In the rat, alpha-MSH stimulates fetal growth, protein synthesis, wound healing and liver regeneration and it reduces periosteal bone resorption. In chick embryos, alpha-MSH restores the corticosteroid-induced growth retardation. Thus alpha-MSH seems to possess general trophic properties. The fetal brain in humans is involved in timing the moment of birth. This process is probably mediated by peptides of the opiomelanocortin family as suggested from observations in anencephaly and other congenital brain anomalies and from the influence of corticosteroids or ACTH on labour. The high percentage of premature deliveries in heroin addicts is worth examining endocrinologically, in this respect. The exact nature of the peptides and mechanisms involved in labour is not yet known. Some peptides of the opiomelanocortin family induce an acceleration of brain development. Neonatal treatment of rats with alpha-MSH alters their later behaviour while ACTH fragments accelerate the onset of eye-opening. Opiates and methadone inhibit brain development, and neonatal administration of beta-endorphin or naloxone causes permanent insensibility to temperature stimuli. The interrelated nature of the fetal pituitary, brain and placenta does not, at present, allow us to pin down which of these structures is primarily involved in the regulation of intrauterine growth, labour and brain development.