Archives of ophthalmology (Chicago, Ill. : 1960) · 2008
Full-field electroretinography and marked variability in clinical phenotype of Alström syndrome.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Malm Eva, Ponjavic Vesna, Nishina Patsy M, Naggert Jürgen K, Hinman Elizabeth G, Andréasson Sten, Marshall Jan D, Möller Claes
Аннотация
OBJECTIVES: To characterize the clinical phenotype and to study the course of disease in patients with Alström syndrome, with an emphasis on retinal function assessed with full-field electroretinography (ERG).
METHODS: Three age- and sex-matched patients with Alström syndrome were selected from our retinitis pigmentosa register for repeated ophthalmologic examinations that included tests for color vision and visual fields using Goldmann perimetry and for repeated assessment of full-field ERGs.
RESULTS: Electroretinography demonstrated cone-rod degeneration in all 3 patients. A concomitant impairment of color vision and visual fields was also observed as well as marked variation in retinal function and in disease severity.
CONCLUSIONS: Full-field ERGs confirmed that Alström syndrome is associated with a cone-rod type of retinal degeneration. In this study, we have shown a striking variability in retinal function and disease onset and severity, which has, to our knowledge, not been described previously in Alström syndrome.
METHODS: Three age- and sex-matched patients with Alström syndrome were selected from our retinitis pigmentosa register for repeated ophthalmologic examinations that included tests for color vision and visual fields using Goldmann perimetry and for repeated assessment of full-field ERGs.
RESULTS: Electroretinography demonstrated cone-rod degeneration in all 3 patients. A concomitant impairment of color vision and visual fields was also observed as well as marked variation in retinal function and in disease severity.
CONCLUSIONS: Full-field ERGs confirmed that Alström syndrome is associated with a cone-rod type of retinal degeneration. In this study, we have shown a striking variability in retinal function and disease onset and severity, which has, to our knowledge, not been described previously in Alström syndrome.
Предметные рубрики MeSH
Abnormalities, MultipleCell Cycle ProteinsChildColor Vision DefectsDNA Mutational AnalysisElectroretinographyFemaleHearing Loss, SensorineuralHumansMutationObesityPhenotypePhotoreceptor Cells, VertebratePolymerase Chain ReactionProteinsRetinitis PigmentosaSyndromeVision DisordersVisual Field TestsVisual Fields