Pakistan journal of pharmaceutical sciences · 2026
Design and optimization of ibuprofen microemulgel using phase titration for effective and enhanced dermal drug delivery.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Nosheen Jaweria Amna, Khalid Sehar, Mubashaar Maiza, Majeed Iqra A, Ashraf Aqsa, Shoaib Quratulain, Hussain Talib
Аннотация
BACKGROUND: The oral administration of ibuprofen is limited due to gastrointestinal adverse effects and inadequate solubility, necessitating the development of enhanced cutaneous delivery systems.
OBJECTIVES: The objective of this study was to create and optimize a microemulgel for ibuprofen to improve solubility, permeability and prolonged release.
METHODS: Microemulsions were prepared using phase titration utilizing Tween 80, butanol and vegetable oil, thereafter incorporating carbopol gel. Preformulation studies encompassed solubility and partition coefficient. Post-formulation characterization involved globule size, zeta potential, pH, drug content and in-vitro/ex-vivo release analyses. Compatibility was evaluated by utilizing FTIR and DSC techniques.
RESULTS: The improved formulation (F3) exhibited a droplet size of 117.5 nm, a zeta potential of -6.47 mV and a drug content of 82.94%. FTIR and DSC analyses validated compatibility. Ex-vivo investigations revealed improved skin permeability and drug release conformed to the Korsmeyer-Pappas model (n = 0.626), signifying non-Fickian diffusion.
CONCLUSION: The formulated ibuprofen microemulgel demonstrated stability, compatibility with skin and prolonged drug release, indicating its potential as an effective option for topical NSAID administration.
OBJECTIVES: The objective of this study was to create and optimize a microemulgel for ibuprofen to improve solubility, permeability and prolonged release.
METHODS: Microemulsions were prepared using phase titration utilizing Tween 80, butanol and vegetable oil, thereafter incorporating carbopol gel. Preformulation studies encompassed solubility and partition coefficient. Post-formulation characterization involved globule size, zeta potential, pH, drug content and in-vitro/ex-vivo release analyses. Compatibility was evaluated by utilizing FTIR and DSC techniques.
RESULTS: The improved formulation (F3) exhibited a droplet size of 117.5 nm, a zeta potential of -6.47 mV and a drug content of 82.94%. FTIR and DSC analyses validated compatibility. Ex-vivo investigations revealed improved skin permeability and drug release conformed to the Korsmeyer-Pappas model (n = 0.626), signifying non-Fickian diffusion.
CONCLUSION: The formulated ibuprofen microemulgel demonstrated stability, compatibility with skin and prolonged drug release, indicating its potential as an effective option for topical NSAID administration.