Allergologia et immunopathologia · 2008
Eliciting doses of positive challenge test in cow's milk allergy are related to cow's milk specific IgE levels.
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García-Ara M C, Boyano M T, Díaz-Pena J M, Quirce S
Аннотация
BACKGROUND: Ingestion of small amounts of cow's milk (CM) can elicit adverse reactions in patients with IgE-mediated CM allergy. Knowing the dose eliciting allergic reactions and the factors affecting it can be of great help in avoiding these reactions.
OBJECTIVE: To analyse the eliciting doses of positive challenge test in patients with CM allergy and to determine its association with the level of CM specific IgE.
METHODS: Ninety-eight positive challenge tests in 56 children, median age of 11 months (3-80) with IgE-mediated CM allergy were retrospectively analysed. Open oral challenge tests were carried out by gradually increasing doses of milk (2-100 ml). The relationship between challenge test doses and CM specific IgE levels were studied.
RESULTS: 18 % of the challenge tests were positive with 2 ml, 24 % with doses between 5 and 10 ml, and the other 58 % with doses between 25 and 100 ml. An inverse association between the doses of the positive challenge test and the level of CM specific- IgE was found, 13.9 kU/L (0.54-> 100 kU/L) when the challenge test was positive with the smaller dose (2 ml); and 1.73 kU/L (< 0.35-76.4 kU/L) with doses above 2 ml (p = 0.0001). The median age of the patients was 13 months (6-49) when the challenge test was positive with 2 ml vs 9 months (3-80) with doses above 2 ml (p = 0.048).
CONCLUSION: The CM specific IgE level and patient's age should be considered in the assessment of the eliciting doses of positive challenge test in CM allergy.
OBJECTIVE: To analyse the eliciting doses of positive challenge test in patients with CM allergy and to determine its association with the level of CM specific IgE.
METHODS: Ninety-eight positive challenge tests in 56 children, median age of 11 months (3-80) with IgE-mediated CM allergy were retrospectively analysed. Open oral challenge tests were carried out by gradually increasing doses of milk (2-100 ml). The relationship between challenge test doses and CM specific IgE levels were studied.
RESULTS: 18 % of the challenge tests were positive with 2 ml, 24 % with doses between 5 and 10 ml, and the other 58 % with doses between 25 and 100 ml. An inverse association between the doses of the positive challenge test and the level of CM specific- IgE was found, 13.9 kU/L (0.54-> 100 kU/L) when the challenge test was positive with the smaller dose (2 ml); and 1.73 kU/L (< 0.35-76.4 kU/L) with doses above 2 ml (p = 0.0001). The median age of the patients was 13 months (6-49) when the challenge test was positive with 2 ml vs 9 months (3-80) with doses above 2 ml (p = 0.048).
CONCLUSION: The CM specific IgE level and patient's age should be considered in the assessment of the eliciting doses of positive challenge test in CM allergy.