Archives of neurology · 2001
Enhancing magnetic resonance imaging lesions and cerebral atrophy in patients with relapsing multiple sclerosis.
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Leist T P, Gobbini M I, Frank J A, McFarland H F
Аннотация
OBJECTIVE: To examine the relation between the frequency of enhancing magnetic resonance imaging lesions and their characteristics of enhancement and atrophy in patients with early relapsing multiple sclerosis.
DESIGN: Analysis of number of enhancing lesions, ventricular volumes and diameters, and lesion characteristics on monthly magnetic resonance imaging scans during natural history follow-up.
SETTING: A clinical research institution.
PATIENTS: Sixteen patients with confirmed early relapsing multiple sclerosis.
MAIN OUTCOME MEASURE: Cerebral atrophy as measured by ventricular enlargement.
RESULTS: Numbers of enhancing lesions correlated well with an increase of ventricular size. This correlation was strongest for patients with a high proportion of concentric ring-enhancing lesions with central contrast pallor.
CONCLUSIONS: Inflammatory events, especially those within lesions with associated blood-brain barrier breakdown, affect the ensuing loss of brain parenchyma. Patients with a high proportion of lesions with central contrast pallor, which is likely associated with more extensive tissue damage, have a higher rate of atrophic changes.
DESIGN: Analysis of number of enhancing lesions, ventricular volumes and diameters, and lesion characteristics on monthly magnetic resonance imaging scans during natural history follow-up.
SETTING: A clinical research institution.
PATIENTS: Sixteen patients with confirmed early relapsing multiple sclerosis.
MAIN OUTCOME MEASURE: Cerebral atrophy as measured by ventricular enlargement.
RESULTS: Numbers of enhancing lesions correlated well with an increase of ventricular size. This correlation was strongest for patients with a high proportion of concentric ring-enhancing lesions with central contrast pallor.
CONCLUSIONS: Inflammatory events, especially those within lesions with associated blood-brain barrier breakdown, affect the ensuing loss of brain parenchyma. Patients with a high proportion of lesions with central contrast pallor, which is likely associated with more extensive tissue damage, have a higher rate of atrophic changes.