Instrumental assessment of myocardial function by doppler tissue imaging in children with congenital heart defects after surgical correction and its correlation with galectin-3 amount as biological marker of cardiac fibrosis.

OBJECTIVE

Introduction

Speed myocardial indicators and estimation of galectin-3 presented for estimation of myocardial dysfunction in children with congenital heart defects (CHD). The aim: Evaluate myocardial function while using tissue Doppler imaging (TDI) and galectin-3 in children with CHD after surgical correction.

PATIENTS AND

METHODS

Materials and methods: We examined 184 children. The study assessed both ventricle systolic and diastolic performance by TDI in combination with tricuspid annular plane systolic excursion (TAPSE). Additionally, systolic (S') and diastolic (ratio E/E') TDI measurements were obtained at the lateral part of mitral annular, interventricular part, and lateral part of tricuspid valve (S`ma lateral, S` ma septal, S`ta lateral та E/E' malateral, E/E' maseptal, E/E' talateral). Galectin-3 amount in serum was detected by immune enzyme method by kit «HumanGalectin-3».

RESULTS

Results

Compared to results of the healthy children systolic TDI measurements in patients with CHD were significantly lower: S` ma lateral 7,81±0,10 сm/s vs 9,85±0,28 сm/s, S` ta lateral 9,70±0,12 сm/s vs 12,8±0,17 сm/s and TAPSE, 1,48±0,02 vs 2,14±0,03 сm/s (р<0,01). Ratio E/E' in patients with CHD were different from results of the healthy children in all myocardial segments: E/Е` ma lateral 7,45±0,21 vs 6,17±0,12, E/Е` ma septal 9,17±0,22 vs 7,54±0,13, E/Е` ta lateral 6,42 ± 0,14 vs 4,64±0,12, (р<0,05). Patients with CHD got galectin-3 content in serum 7,04±0,21 ng/ml vs 4,17±0,17 ng/ml (р<0,01) results of the healthy children.

CONCLUSION

Conclusions

Analyze of TDI measurements and galectin-3 content allows evaluate myocardial dysfunction in asymptomatic patients with CHD after surgical correction.