Salud publica de Mexico · 2018
Prevention and control of neoplasms associated with HPV in high-risk groups in Mexico City: The Condesa Study.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Lazcano-Ponce Eduardo, Salmerón Jorge, González Andrea, Allen-Leigh Betania, León-Maldonado Leith, Magis Carlos, Aranda-Flores Carlos, Conde-González Carlos, Portillo-Romero Alejandra Jalil, Yunes-Díaz Elsa, Rivera-Rivera Leonor, Vargas Galileo, Nyitray Alan G, Giuliano Anna R
Аннотация
OBJECTIVE: To evaluate the effectiveness of a combined strategy of human papillomavirus virus (HPV) vaccination and high-risk HPV screening to reduce the occurrence of anogenital and oropharyngeal neoplasms among men who have sex with men, people with HIV, homeless people, transgender women, female sex workers and rape victims.
MATERIALS AND METHODS: This mixed methods study evaluates the effectiveness of a combined vaccination-screening strategy to reduce HPV prevalence/incidence and occurrence of cervical intraepithelial neoplasms grade 2+ and/or anal intraepithelial neoplasms grade 2+, using Kaplan-Meier. The time-to-event method will evaluate time from positive results for specific anogenital HPV to incidence of anogenital lesions containing that HPV type.
RESULTS: People vaccinated against HPV and screened for HPV as a primary test will have lower prevalence and incidence of HPV infection and consequently lower frequency of HPV-related anogenital and oropharyngeal lesions.
CONCLUSIONS: Thisstudy will generate scientific evidence on effectiveness of a combined vaccination-screening strategy to reduce the burden of HPV-associated neoplasms.
MATERIALS AND METHODS: This mixed methods study evaluates the effectiveness of a combined vaccination-screening strategy to reduce HPV prevalence/incidence and occurrence of cervical intraepithelial neoplasms grade 2+ and/or anal intraepithelial neoplasms grade 2+, using Kaplan-Meier. The time-to-event method will evaluate time from positive results for specific anogenital HPV to incidence of anogenital lesions containing that HPV type.
RESULTS: People vaccinated against HPV and screened for HPV as a primary test will have lower prevalence and incidence of HPV infection and consequently lower frequency of HPV-related anogenital and oropharyngeal lesions.
CONCLUSIONS: Thisstudy will generate scientific evidence on effectiveness of a combined vaccination-screening strategy to reduce the burden of HPV-associated neoplasms.
Предметные рубрики MeSH
AdultAnus NeoplasmsCarcinoma in SituComorbidityCrime VictimsEarly Detection of CancerFemaleHIV InfectionsHumansImmunization ProgramsMaleMexicoMouth NeoplasmsPapillomavirus InfectionsPapillomavirus VaccinesProgram EvaluationRiskSexual BehaviorSexual and Gender MinoritiesSocial MarginalizationUrban PopulationUterine Cervical NeoplasmsVaccinationVulnerable PopulationsYoung AdultUterine Cervical Dysplasia