Pakistan journal of pharmaceutical sciences · 2026
Intravaginal Aloe barbadensis and cervical HPV clearance: A retrospective observational study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Gozde Ozdemir Belma, Avci Fazil, Huseynli Leyla, Dolas Rana, Bilgi Ahmet, Celik Cetin
Аннотация
BACKGROUND: Persistent infection with human papillomavirus (HPV) is a key factor in cervical carcinogenesis. Immune-mediated mechanisms play a central role in viral clearance, leading to interest in immunomodulatory supportive therapies.
OBJECTIVES: This study aimed to evaluate the association between intravaginal Aloe barbadensis use and HPV clearance in HPV-positive women.
METHODS: This retrospective observational study included 251 HPV-positive women aged ≥30 years. Of these, 164 received intravaginal Aloe barbadensis-containing vaginal capsules for 10 days, while 87 received no immunomodulatory treatment. HPV-PCR and cytological results were evaluated at baseline and after one year of follow-up.
RESULTS: HPV clearance was observed in 45.7% of patients in the Aloe barbadensis group and 36.8% in the control group, with no statistically significant difference between groups (p = 0.219). Subgroup analyses based on smoking status and HPV genotype also revealed no significant differences in clearance rates.
CONCLUSION: Intravaginal Aloe barbadensis use was not associated with a statistically significant improvement in HPV clearance. The findings highlight the complexity of HPV persistence and suggest that single-agent immunomodulatory interventions may have limited clinical impact.
OBJECTIVES: This study aimed to evaluate the association between intravaginal Aloe barbadensis use and HPV clearance in HPV-positive women.
METHODS: This retrospective observational study included 251 HPV-positive women aged ≥30 years. Of these, 164 received intravaginal Aloe barbadensis-containing vaginal capsules for 10 days, while 87 received no immunomodulatory treatment. HPV-PCR and cytological results were evaluated at baseline and after one year of follow-up.
RESULTS: HPV clearance was observed in 45.7% of patients in the Aloe barbadensis group and 36.8% in the control group, with no statistically significant difference between groups (p = 0.219). Subgroup analyses based on smoking status and HPV genotype also revealed no significant differences in clearance rates.
CONCLUSION: Intravaginal Aloe barbadensis use was not associated with a statistically significant improvement in HPV clearance. The findings highlight the complexity of HPV persistence and suggest that single-agent immunomodulatory interventions may have limited clinical impact.