AIDS research and human retroviruses · 2026
Frailty, Physical Function Impairment, and Pulmonary Function in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Abdo Mona, Kunisaki Ken M, Morris Alison, Stosor Valentina, Chang Dong, D'Souza Gypsyamber, Crothers Kristina, Abdel-Maksoud Madiha, DiGuiseppi Carolyn, Brown Todd T, MaWhinney Samantha, Erlandson Kristine M
Аннотация
People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals aging without HIV. We examined whether baseline physical function was associated with subsequent pulmonary impairments. Associations of frailty and physical function (gait speed [m/s], grip strength [kg]) with pulmonary function (<80% predicted diffusing capacity for carbon monoxide [DLCO] and forced expiratory volume [FEV1]) 3 years later were modeled; age, HIV status, and smoking were assessed as effect modifiers. Among 1,024 men (54% PAWH, 10% frail, 51% prefrail), mean (SD) age = 53 (12) years, cumulative smoking = 12 (19) pack-years, gait speed = 1.1 (0.2) m/s, and grip strength = 36.6 (9.2) kg. Frailty, prefrailty, and weak grip strength were associated with higher odds of subsequent impaired DLCO and FEV1. Slow gait speed was associated with higher odds of DLCO impairment but not FEV1. No statistically significant modifications were found. Interventions to improve physical function may help preserve pulmonary function.