[The clinical characteristics of 151 cases of Budd-Chiari syndrome].

OBJECTIVE

To summarize the clinical features of Budd-Chiari syndrome.

METHODS

A total of 151 Budd-Chiari syndrome admitted in Peking University People's Hospital from 1996 to 2012 were analyzed retrospectively.

RESULTS

Abdominal distension was the most common complaint, with 62.9% (95/151) of lower extremity edema, 53.0% (80/151) of typical bottom-up flow of the abdominal wall longitudinal varicose veins and 60.9% (92/151) with ascites. Laboratory tests results showed median of alanine aminotransferase (ALT) was 21.5 (15.0, 30.0) U/L, aspartate aminotransferase (AST) was 30.0 (23.8, 42.0) U/L, total bilirubin was 31.1(23.3, 47.8) µmol/L, blood albumin 37.5 was (31.8, 41.5) g/L, prothrombin activity was 71% (61%, 84%). WBC was 5.2 (3.5, 7.5) ×10(9)/L, hemoglobin concentration was 126.5 (108.8, 144.2) g/L, and platelet count was 117.0 (85.5, 155.5)×10(9)/L. Abdominal B-ultrasound examination showed hepatomegaly existed in 68.9% (104/151) patients.Intraoperative angiography and surgical exploration showed that 41.1% (62/151) patients were simple inferior vena cava obstruction or stenosis, 15.9% (24/151) were simple hepatic vein obstruction or stenosis and 43.0% (65/151) suffered from the inferior vena cava combined with hepatic vein stenosis or obstruction.Surgically confirmation of the lesions showed that inferior vena cava membrane-like structure combined with thrombosis was in 59.6% (90/151) cases.

CONCLUSIONS

Liver congestion, inferior vena cava congestion and portal hypertension are the main clinical manifestations of Budd-Chiari syndrome.With slightly liver function injury, liver dysfunction of Budd-Chiari syndrome isn't parallel with its portal hypertension.