Minor non-fermenting Gram-negative bacilli in Europe, 2020-2024 (MINOFEu).
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Bianco Gabriele, Bastos Paulo, Gartzonika Konstantina, Christaki Eirini, Mavromanolaki Viktoria Eirini, Maraki Sofia, Spiliopoulou Anastasia, Giormezis Nikolaos, Lengerova Gergana, Kalchev Yordan, Budimir Ana, Bedenić Branka, Rubic Zana, Saskor Antonija, Milanovic Karla, Licker Monica, Musuroi Corina, Juhász Emese, Kristóf Katalin, Pirs Mateja, Velimirovic Ivana, Berktold Michael, Krajčíková Adriána, Gryndlerova Anezka, Drevinek Pavel, Sedláková Miroslava Htoutou, Kolář Milan, Brzychczy-Wloch Monika, Olechowska-Jarząb Aldona, Brauncajs Małgorzata, Bielec Filip, Seliga-Gąsior Dominika, Podsiadly Edyta, Riesbeck Kristian, Andersson Hanna-Sofia, Tønjum Tone, Berild Johan Christian, Leegaard Truls Michael, Nellemann Rasmussen Asger, Schønning Kristian, Glöckner Stefan, Rödel Jürgen, Posadas-Cantera Sara, Badr Mohamed Tarek, Kintzinger Tim, Schaumburg Frieder, Thelen Philipp, Hamprecht Axel, Dudakova Anna, Jantsch Jonathan, Hoffmann Katharina, Kaasch Achim J, Jacot Damien, Greub Gilbert, Landi Jessica, Ambretti Simone, Comini Sara, Chiatamone Ranieri Sofia, Serretiello Enrica, Franci Gianluigi, Fasciana Teresa, Schade Rogier, Yusuf Erlangga, van Kleef-van Koeveringe Stefanie, Vandamme Sarah, Verroken Alexia, Rodriguez-Villalobos Hector, Strubbe Gregory, Vandendriessche Stien, Rabeau Pauline, Corvec Stéphane, Dubois Damien, Massip Clémence, Chainier Delphine, Barraud Olivier, Mizrahi Assaf, Bacho Célia, Bouchiat Coralie, Fatah Tayssir, Marchandin Hélène, Jean-Pierre Vincent, Ali Saied, O'Donnell Sinead, Doyle Maeve, Ramsamaroo Zachary, Egan Clarice, McNicholas Sinead, Helgason Kristján Orri, Öngen Betigül, Karapınar Bahar Akgün, Oyardı Özlem, Aksu Burak, Colomina-Rodriguez Javier, Torres Ignacio, Gilarranz Luengo Raul, Larrosa Escartín Maria Nieves, Viñado Perez Maria Belen, Halperin Ana Verónica, Cantón Rafael, Seruca Miguel, Santos Mendes Vasco, Volovetska Yuliya, Melo Cristino José, Costa Cristina, Boattini Matteo
Аннотация
METHODS: We conducted a multicentre retrospective observational study analysing all minor NFGNB isolates recovered from blood cultures in 56 European Hospital Centres over a 5-year period (2020-2024). Diagnostic approach, epidemiology and antimicrobial susceptibility according to European Committee on Antimicrobial Susceptibility Testing v. 15.0 were investigated.
RESULTS: A total of 4420 minor NFGNB isolates were included. In 43.6% of cases, the isolates were recovered from polymicrobial blood cultures, and 40.6% were detected during microbiologically defined catheter-related bloodstream infections. Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-ToF) mass spectrometry was the most widely used tool for species identification (98%). Antimicrobial susceptibility testing was conducted in all centres, using mostly broth microdilution commercial systems (57%), disk diffusion (57%) and gradient diffusion MIC strip (54%) methods, mainly according to European Committee on Antimicrobial Susceptibility Testing guidelines (67.9%). The most prevalent species were Stenotrophomonas maltophilia (52.4%), Achromobacter xylosoxidans (7.8%), Sphingomonas paucimobilis (5.3%) and the Burkholderia cepacia complex (4.8%). S. maltophilia displayed a high rate of resistance to sulfamethoxazole/trimethoprim (11%), and 2% of the isolates were found to be likely resistant to cefiderocol. A. xylosoxidans showed high resistance to meropenem (10%), piperacillin/tazobactam (24%) and sulfamethoxazole/trimethoprim (53%) when tested by MIC methods, while showing over 90% susceptibility to meropenem when tested by disk diffusion. S. paucimobilis displayed over 90% susceptibility to amoxicillin/clavulanate, ampicillin/sulbactam, imipenem, meropenem and tetracycline.
CONCLUSIONS: This study provides an updated overview of the diagnostic approaches and epidemiology of minor NFGNB across Europe, supporting future comparative analyses and improved diagnostic and antimicrobial strategies.