BJOG : an international journal of obstetrics and gynaecology · 2007
Magnesium supplementation and perinatal hypoxia: outcome of a parallel group randomised trial in pregnancy.
СтатьяМногоцентровое исследованиеРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Harrison V, Fawcus S, Jordaan E
Аннотация
OBJECTIVE: To determine the effects of magnesium supplementation in pregnancy on the incidence of hypoxic-ischaemic encephalopathy (HIE).
DESIGN: A randomised double-blind placebo-controlled study.
SETTING: A Midwife Obstetric Unit and its two referral hospitals in Cape Town, South Africa.
POPULATION: A group of 4494 black pregnant women of low socio-economic status.
METHOD: Mothers, from the time of booking until delivery, were randomised to receive two identical tablets daily, containing either 128 mg slow-release magnesium stearate or lactose sugar.
MAIN OUTCOME MEASURES: Primary: The incidence of HIE. Secondary: The incidence of fetal heart rate decelerations, term Stillbirths, Low Apgar Scores, Meconium Aspiration Pneumonia.
RESULTS: The incidence of HIE (0.9%) was considerably less than anticipated (2%). There were 22 infants in the placebo group and 15 infants in the supplemented group (P = 0.279). The difference was not significant. Secondary outcomes such as late fetal heart rate decelerations (P = 0.002) and term stillbirths (P = 0.016) were reduced significantly in the supplemented group, but this finding needs further substantiation.
CONCLUSIONS: Magnesium supplementation did not reduce the incidence of HIE significantly, probably because the study was underpowered and compliance was relatively poor.
DESIGN: A randomised double-blind placebo-controlled study.
SETTING: A Midwife Obstetric Unit and its two referral hospitals in Cape Town, South Africa.
POPULATION: A group of 4494 black pregnant women of low socio-economic status.
METHOD: Mothers, from the time of booking until delivery, were randomised to receive two identical tablets daily, containing either 128 mg slow-release magnesium stearate or lactose sugar.
MAIN OUTCOME MEASURES: Primary: The incidence of HIE. Secondary: The incidence of fetal heart rate decelerations, term Stillbirths, Low Apgar Scores, Meconium Aspiration Pneumonia.
RESULTS: The incidence of HIE (0.9%) was considerably less than anticipated (2%). There were 22 infants in the placebo group and 15 infants in the supplemented group (P = 0.279). The difference was not significant. Secondary outcomes such as late fetal heart rate decelerations (P = 0.002) and term stillbirths (P = 0.016) were reduced significantly in the supplemented group, but this finding needs further substantiation.
CONCLUSIONS: Magnesium supplementation did not reduce the incidence of HIE significantly, probably because the study was underpowered and compliance was relatively poor.