Internal medicine (Tokyo, Japan) · 2017
Clinical Presentation of Tubulointerstitial Nephritis Caused by Amyloid Light-chain Amyloidosis in a Patient with Sjögren's Syndrome.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Inoue Reiko, Fujigaki Yoshihide, Kobayashi Kana, Tamura Yoshifuru, Ota Tatsuru, Shibata Shigeru, Ishida Tsuyoshi, Kondo Fukuo, Yamaguchi Yutaka, Uchida Shunya
Аннотация
We report a 70-year-old woman with Sjögren's syndrome who had severe renal dysfunction with mild proteinuria and elevated urinary low-molecular-weight proteins. Based on these clinical presentations, interstitial nephritis due to Sjögren's syndrome was strongly suspected. Unexpectedly, renal pathology revealed amyloid light-chain (AL) lambda-type depositions predominantly in the vasculatures with severe tubulointerstitial damage. Concentrated urine immunofixation was positive for Bence Jones lambda-type monoclonal proteins. Given the involvement in other organs, systemic AL amyloidosis was diagnosed. The patient underwent chemotherapy, but hemodialysis was ultimately instituted. It should be remembered that renal amyloidosis occurs as a clinical presentation of interstitial nephritis.