Fertility and sterility · 2002
Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women.
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Calvo Rosa M, Tellería Dolores, Sancho José, San Millán José L, Escobar-Morreale Héctor F
Аннотация
OBJECTIVE: To determine if the insulin gene variable number of tandem repeats (VNTR) regulatory polymorphism is associated with hyperandrogenism in a population of Spanish women.
DESIGN: Controlled clinical study.
SETTING: Tertiary institutional hospital.
PATIENT(S): Ninety-six hyperandrogenic patients and 38 healthy control women.
INTERVENTION(S): Whole blood and serum samples were collected during the follicular phase of the menstrual cycle.
MAIN OUTCOME MEASURE(S): Insulin gene VNTR regulatory polymorphism genotypes (classes I/I, I/III, and III/III alleles) and serum androgen levels. Insulin resistance was estimated from fasting glucose and insulin levels by using the homeostatic model assessment.
RESULT(S): The frequencies of VNTR genotypes were 45.5%, 43.3%, and 11.2% for I/I, I/III, and III/III alleles considering patients and controls as a whole. These frequencies were not statistically different in controls (47.4%, 34.2%, and 18.4%) and in patients (44.8%, 46.9%, and 8.3%).
CONCLUSION(S): Hyperandrogenism and the insulin gene VNTR regulatory polymorphism are not associated in Spanish women.
DESIGN: Controlled clinical study.
SETTING: Tertiary institutional hospital.
PATIENT(S): Ninety-six hyperandrogenic patients and 38 healthy control women.
INTERVENTION(S): Whole blood and serum samples were collected during the follicular phase of the menstrual cycle.
MAIN OUTCOME MEASURE(S): Insulin gene VNTR regulatory polymorphism genotypes (classes I/I, I/III, and III/III alleles) and serum androgen levels. Insulin resistance was estimated from fasting glucose and insulin levels by using the homeostatic model assessment.
RESULT(S): The frequencies of VNTR genotypes were 45.5%, 43.3%, and 11.2% for I/I, I/III, and III/III alleles considering patients and controls as a whole. These frequencies were not statistically different in controls (47.4%, 34.2%, and 18.4%) and in patients (44.8%, 46.9%, and 8.3%).
CONCLUSION(S): Hyperandrogenism and the insulin gene VNTR regulatory polymorphism are not associated in Spanish women.
Предметные рубрики MeSH
17-alpha-HydroxyprogesteroneAdultAllelesAndrostenedioneBlood GlucoseBody Mass IndexDehydroepiandrosterone SulfateEstradiolFemaleHirsutismHomozygoteHumansHyperandrogenismInsulinInsulin ResistanceMinisatellite RepeatsPolycystic Ovary SyndromePolymorphism, GeneticSex Hormone-Binding GlobulinSpainTestosterone