Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique · 2017
[Local failures of nasopharynx carcinoma: Anatomoclinical aspects and therapeutic results].
СтатьяНазвание и аннотация: Перевод в очереди
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Ghorbal L, Elloumi F, Siala W, Khabir A, Ghorbel A, Frikha M, Daoud J
Аннотация
PURPOSE: Retrospective analysis of clinical aspects and therapeutic results of nasopharynx cancer local failures.
PATIENTS AND METHODS: Forty patients with local failure with or without nodal involvement of nasopharyngeal carcinoma were treated between 1993 and 2013. Reirradiation of nasopharynx was delivered at the dose of 60Gy. Platinum-based chemotherapy was indicated in case of locally advanced disease and/or associated nodal failure.
RESULTS: The mean age at diagnosis of primitive tumour was 41.9 years (26-67 years). The mean time of relapse occurrence was 31.7 months (6-104 months). Sixty five percent of failures were confined to the nasopharynx. Nodal failure was seen in 14 cases. Twenty-eight patients had chemotherapy. Twenty-five patients had reirradiation of nasopharynx. Mean follow-up was 98 months (12-191 months). Fourteen patients were still alive and in complete remission. Five-year survival was 40.7%. Xerostomia was the most frequent late toxicity. No haemorrhage was seen.
CONCLUSION: Reirradiation is the mainstay treatment of nasopharyngeal local failure. Late toxicity seems to decrease with novel techniques of reirradiation.
PATIENTS AND METHODS: Forty patients with local failure with or without nodal involvement of nasopharyngeal carcinoma were treated between 1993 and 2013. Reirradiation of nasopharynx was delivered at the dose of 60Gy. Platinum-based chemotherapy was indicated in case of locally advanced disease and/or associated nodal failure.
RESULTS: The mean age at diagnosis of primitive tumour was 41.9 years (26-67 years). The mean time of relapse occurrence was 31.7 months (6-104 months). Sixty five percent of failures were confined to the nasopharynx. Nodal failure was seen in 14 cases. Twenty-eight patients had chemotherapy. Twenty-five patients had reirradiation of nasopharynx. Mean follow-up was 98 months (12-191 months). Fourteen patients were still alive and in complete remission. Five-year survival was 40.7%. Xerostomia was the most frequent late toxicity. No haemorrhage was seen.
CONCLUSION: Reirradiation is the mainstay treatment of nasopharyngeal local failure. Late toxicity seems to decrease with novel techniques of reirradiation.
Предметные рубрики MeSH
AdultAgedAntineoplastic Agents, AlkylatingCarcinomaCombined Modality TherapyFemaleFollow-Up StudiesHearing Loss, SensorineuralHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeoadjuvant TherapyNeoplasm Recurrence, LocalOrganoplatinum CompoundsOsteosclerosisRadiotherapy, High-EnergyRetrospective StudiesSalvage TherapyTreatment OutcomeXerostomia