The Journal of neuropsychiatry and clinical neurosciences · 1989
Single photon emission computed tomography (SPECT) with [123I]IMP in the differential diagnosis of psychiatric disorders.
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O'Connell R A, Van Heertum R L, Billick S B, Holt A R, Gonzalez A, Notardonato H, Luck D, King L N
Аннотация
Single photon emission computed tomography (SPECT) with [123I]N-isopropyl iodoamphetamine--[123I]IMP--was used to study regional cerebral blood flow (rCBF) in 94 psychiatric patients and six controls. Patients with dementias had distinct brain-image patterns, consistent with the expected neuropathology. Major depressives had decreased cortical and subcortical rCBF. Increased caudate rCBF was observed in schizophrenics and other psychoses with positive symptoms. SPECT is a practical method of functional brain imaging with potential in the differential diagnosis of neuropsychiatric disorders. Further studies are needed to assess the effect of other variables on brain-image patterns.
Предметные рубрики MeSH
AIDS Dementia ComplexAdultAlzheimer DiseaseAmphetaminesBipolar DisorderBrainBrain MappingCaudate NucleusCerebral CortexDepressive DisorderDiagnosis, DifferentialFemaleHumansIodine RadioisotopesIofetamineMaleMiddle AgedNeurocognitive DisordersPsychotic DisordersRegional Blood FlowSchizophreniaSchizophrenic PsychologyTomography, Emission-Computed, Single-Photon