Nature communications · 2023
A parabrachial-hypothalamic parallel circuit governs cold defense in mice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Yang Wen Z, Xie Hengchang, Du Xiaosa, Zhou Qian, Xiao Yan, Zhao Zhengdong, Jia Xiaoning, Xu Jianhui, Zhang Wen, Cai Shuang, Li Zhangjie, Fu Xin, Hua Rong, Cai Junhao, Chang Shuang, Sun Jing, Sun Hongbin, Xu Qingqing, Ni Xinyan, Tu Hongqing, Zheng Ruimao, Xu Xiaohong, Wang Hong, Fu Yu, Wang Liming, Li Xi, Yang Haitao, Yao Qiyuan, Yu Tian, Shen Qiwei, Shen Wei L
Аннотация
Thermal homeostasis is vital for mammals and is controlled by brain neurocircuits. Yet, the neural pathways responsible for cold defense regulation are still unclear. Here, we found that a pathway from the lateral parabrachial nucleus (LPB) to the dorsomedial hypothalamus (DMH), which runs parallel to the canonical LPB to preoptic area (POA) pathway, is also crucial for cold defense. Together, these pathways make an equivalent and cumulative contribution, forming a parallel circuit. Specifically, activation of the LPB → DMH pathway induced strong cold-defense responses, including increases in thermogenesis of brown adipose tissue (BAT), muscle shivering, heart rate, and locomotion. Further, we identified somatostatin neurons in the LPB that target DMH to promote BAT thermogenesis. Therefore, we reveal a parallel circuit governing cold defense in mice, which enables resilience to hypothermia and provides a scalable and robust network in heat production, reshaping our understanding of neural circuit regulation of homeostatic behaviors.