Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025
Children and adolescents living with human immunodeficiency virus/acquired immunodeficiency syndrome in a tertiary hospital in southern Brazil.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Silveira Savas Sobral, Bolinsenha Marina Pinheiro da Silva, Rossoni Yasmin Oliveira, Silveira Sinis Sobral, Lugarini Giuliana, Tahan Tony Tannous, Hirose Tatiane Emi, Rodrigues Cristina de Oliveira, Caprilhone Lucca Weffort, Rossoni Andrea Maciel de Oliveira, Gabardo Betina Mendez Alcântara
Аннотация
OBJECTIVE: The aim of the study was to describe the clinical and epidemiological features of pediatric patients living with human immunodeficiency virus in a tertiary care service in southern Brazil and the types of antiretroviral therapy (ART) used, and to compare the immunological and virological profiles at diagnosis and at the present time.
METHODS: This longitudinal, observational study involved retrospective data collection, evaluating the clinical, immunological, and virological profiles of patients treated at a pediatric infectious disease outpatient clinic in a tertiary care center in Paraná during 2022.
RESULTS: A total of 52 patients were included. Median age at diagnosis was 4.0 years; current median age, 10.5 years; 55.7% were girls. Most (86.5%) were cared for by parents or extended family, and 9.6% were on a second-line ART regimen. Neuropsychiatric alterations occurred in 26.9%; dyslipidemia in 66.0%. The frequency of immunosuppressed patients decreased from 35.3% to 24.4%, and the frequency of clinical symptoms from 11.6 to 1.9% (both p<0.05). The mean viral load (log) dropped from 4.62 to 3.01. No statistically significant associations were found between age, duration of follow-up, or regularity of follow-up and clinical changes.
CONCLUSIONS: The use of ART effectively reduced viral load, symptoms, and immunosuppression. Despite improvements, a considerable percentage still shows positive viral load, indicating risk of future complications.
METHODS: This longitudinal, observational study involved retrospective data collection, evaluating the clinical, immunological, and virological profiles of patients treated at a pediatric infectious disease outpatient clinic in a tertiary care center in Paraná during 2022.
RESULTS: A total of 52 patients were included. Median age at diagnosis was 4.0 years; current median age, 10.5 years; 55.7% were girls. Most (86.5%) were cared for by parents or extended family, and 9.6% were on a second-line ART regimen. Neuropsychiatric alterations occurred in 26.9%; dyslipidemia in 66.0%. The frequency of immunosuppressed patients decreased from 35.3% to 24.4%, and the frequency of clinical symptoms from 11.6 to 1.9% (both p<0.05). The mean viral load (log) dropped from 4.62 to 3.01. No statistically significant associations were found between age, duration of follow-up, or regularity of follow-up and clinical changes.
CONCLUSIONS: The use of ART effectively reduced viral load, symptoms, and immunosuppression. Despite improvements, a considerable percentage still shows positive viral load, indicating risk of future complications.