Nephrologie · 1985
[Risk of bone disease as a result of fluoride intake in chronic renal insufficiency].
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Noël C, Gosselin B, Dracon M, Pagniez D, Lemaguer D, Lemaître L, Dhondt J L, Lelièvre G, Tacquet A
Аннотация
Four cases of osteosclerosis were observed in patients with renal failure. All subjects presented with moderate reduction in renal function which had been stabilized for several years. Osteosclerosis appeared progressively but was clinically symptomatic in only one patient. Fluoride intoxication was ascertained on the basis of X-ray examination and bone biopsy. In addition, the source of fluoride intoxication was easily recognized as the drinking water (2 to 3 1/day), "Vichy Saint Yorre" commercial mineral water (fluoride concentration 9 mg/l) in 3 cases, and tap water in the fourth case. These observations emphasize the risk of high chronic fluoride intake in patients with renal failure, even with mild reduction of glomerular filtration rate.