Orthodontics & craniofacial research · 2003
The prenatal development of the human cerebellar field in Down syndrome.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Lomholt J F, Keeling J W, Hansen B F, Ono T, Stoltze K, Kjaer I
Аннотация
OBJECTIVES: To describe the development of the osseous field enclosing the cerebellum and part of the brain stem (the neuro-osteological cerebellar field) in Down syndrome, and compare the development with normal developmental standard of the field.
DESIGN: Radiographic, cephalometric and histologic examination of 58 legally or spontaneously aborted Down syndrome prenatal human fetuses; crown-rump length of 80-255 mm and approximate gestational age from 13 to 26 weeks.
RESULTS: The growth of the Down syndrome cerebellar field is smaller in the sagittal and vertical directions than in normal fetuses.
CONCLUSION: In the present study the pathological development of the cerebellar field was described in a genotypic sample. In combining normal and pathological development of neural and osseous tissues a better understanding of the genotype/phenotype interactions is attainable and fields of common gene expression maybe defined.
DESIGN: Radiographic, cephalometric and histologic examination of 58 legally or spontaneously aborted Down syndrome prenatal human fetuses; crown-rump length of 80-255 mm and approximate gestational age from 13 to 26 weeks.
RESULTS: The growth of the Down syndrome cerebellar field is smaller in the sagittal and vertical directions than in normal fetuses.
CONCLUSION: In the present study the pathological development of the cerebellar field was described in a genotypic sample. In combining normal and pathological development of neural and osseous tissues a better understanding of the genotype/phenotype interactions is attainable and fields of common gene expression maybe defined.