Journal of the science of food and agriculture · 2025
Preparation and characterization of novel nanoparticles using waxy and non-waxy proso millet protein, NaCas and EGCG for efficient delivery of Cur.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fan Yuting, Ren Jing, Li Xinyi, Yao Yang, Zhang Pingping, Du Shuang-Kui
Аннотация
BACKGROUND: Proso millet protein (PMP) has attracted increasing attention as a plant-based carrier for hydrophobic bioactives, yet its poor stability and solubility limit its application.
RESULTS: In this study, waxy (W-YS1) and non-waxy (N-YM2) PMP were used to fabricate Cur-EGCG-NaCas-P-1 (2) complex nanoparticles via anti-solvent precipitation for curcumin (Cur) delivery. Under optimal fabrication conditions (pH 3.0 or 7.0, Cur/PMP ratio of 1:5, and epigallocatechin-3-gallate (EGCG) concentration of 1.2 mg mL-1), Cur was successfully encapsulated into PMP-based nanoparticles. The incorporation of EGCG markedly enhanced the physical stability, encapsulation efficiency, and antioxidant activity of the nanoparticles. X-ray diffraction analysis confirmed that Cur existed in an amorphous state after encapsulation, while Fourier transform infrared and fluorescence spectroscopy revealed that electrostatic interactions, hydrophobic interactions, and hydrogen bonding were the main driving forces for nanoparticle formation. Furthermore, Cur bioaccessibility was significantly improved in a simulated gastrointestinal environment.
CONCLUSION: These results indicate that PMP/NaCas/EGCG complex nanoparticles represent a promising protection and delivery system for hydrophobic bioactive compounds, with considerable potential for applications in functional foods and pharmaceutical formulations. © 2025 Society of Chemical Industry.
RESULTS: In this study, waxy (W-YS1) and non-waxy (N-YM2) PMP were used to fabricate Cur-EGCG-NaCas-P-1 (2) complex nanoparticles via anti-solvent precipitation for curcumin (Cur) delivery. Under optimal fabrication conditions (pH 3.0 or 7.0, Cur/PMP ratio of 1:5, and epigallocatechin-3-gallate (EGCG) concentration of 1.2 mg mL-1), Cur was successfully encapsulated into PMP-based nanoparticles. The incorporation of EGCG markedly enhanced the physical stability, encapsulation efficiency, and antioxidant activity of the nanoparticles. X-ray diffraction analysis confirmed that Cur existed in an amorphous state after encapsulation, while Fourier transform infrared and fluorescence spectroscopy revealed that electrostatic interactions, hydrophobic interactions, and hydrogen bonding were the main driving forces for nanoparticle formation. Furthermore, Cur bioaccessibility was significantly improved in a simulated gastrointestinal environment.
CONCLUSION: These results indicate that PMP/NaCas/EGCG complex nanoparticles represent a promising protection and delivery system for hydrophobic bioactive compounds, with considerable potential for applications in functional foods and pharmaceutical formulations. © 2025 Society of Chemical Industry.