Acta cirurgica brasileira · 2020
Therapeutic effects of vitamin D on acetic acid-induced colitis in rats.
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bademci Refik, Erdoğan Mümin Alper, Kara Ali Yücel, Yiğittürk Gürkan, Erbaş Oytun
Аннотация
PURPOSE: To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model.
METHODS: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 µg/kg for 5 days.
RESULTS: Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p <0.000).
CONCLUSION: The findings suggest that calcitriol may be an agent that could be used in acute colitis treatment.
METHODS: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 µg/kg for 5 days.
RESULTS: Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p <0.000).
CONCLUSION: The findings suggest that calcitriol may be an agent that could be used in acute colitis treatment.
Предметные рубрики MeSH
Acute DiseaseAnimalsAnti-Inflammatory AgentsC-Reactive ProteinCalcitriolColitisDisease Models, AnimalLipid PeroxidationMaleMalondialdehydeOxidative StressRandom AllocationRats, Sprague-DawleyReference ValuesReproducibility of ResultsSerum Amyloid P-ComponentTreatment OutcomeTumor Necrosis Factor-alphaPentraxins