European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2014
Inhibitory effects of children's toothpastes on Streptococcus mutans, Streptococcus sanguinis and Lactobacillus acidophilus.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Evans A, Leishman S J, Walsh L J, Seow W K
Аннотация
AIM: As suppression of Streptococcus mutans in young children may prevent or delay colonisation of the oral cavity, toothbrushing with dentifrices containing anti-S. mutans activity may aid in preventing caries. The aims of this study were to compare the effects of children's dentifrices on the growth of S. mutans and non-mutans bacteria (Streptococcus sanguinis and Lactobacillus acidophilus).
MATERIALS AND METHODS: The agar diffusion assay at neutral pH was used to examine the antibacterial activity of commercial dentifrices and their major constituents.
RESULTS: Dentifrices containing 1,450 ppm fluoride produced greater growth inhibition of both S. mutans and S. sanguinis than those with <500 ppm. No inhibition was seen for pure solutions of sodium fluoride or sodium monofluorophosphate at fluoride concentrations up to 100,000 ppm. Stannous fluoride exerted antibacterial effects at concentrations above 10,000 ppm. Significant growth inhibition of both S. mutans and S. sanguinis was seen with sodium lauryl sulphate at 2,500 ppm and with triclosan at 100 ppm. No inhibitory effects were seen for xylitol, sorbitol, sodium pyrophosphate or polyethylene glycol at concentrations up to 80,000 ppm.
CONCLUSION: Sodium lauryl sulphate is the major bacterial inhibitory compound in children's dentifrices.
MATERIALS AND METHODS: The agar diffusion assay at neutral pH was used to examine the antibacterial activity of commercial dentifrices and their major constituents.
RESULTS: Dentifrices containing 1,450 ppm fluoride produced greater growth inhibition of both S. mutans and S. sanguinis than those with <500 ppm. No inhibition was seen for pure solutions of sodium fluoride or sodium monofluorophosphate at fluoride concentrations up to 100,000 ppm. Stannous fluoride exerted antibacterial effects at concentrations above 10,000 ppm. Significant growth inhibition of both S. mutans and S. sanguinis was seen with sodium lauryl sulphate at 2,500 ppm and with triclosan at 100 ppm. No inhibitory effects were seen for xylitol, sorbitol, sodium pyrophosphate or polyethylene glycol at concentrations up to 80,000 ppm.
CONCLUSION: Sodium lauryl sulphate is the major bacterial inhibitory compound in children's dentifrices.
Предметные рубрики MeSH
Anti-Bacterial AgentsAnti-Infective Agents, LocalCariostatic AgentsChildDentifricesDiphosphatesFluoridesHumansLactobacillus acidophilusPhosphatesPolyethylene GlycolsSodium Dodecyl SulfateSodium FluorideSorbitolStreptococcus mutansStreptococcus sanguisSurface-Active AgentsSweetening AgentsTin FluoridesToothpastesTriclosanXylitol